Xenbase Image ID: 81292

Figure 1. Mesodermal BMP2 Signals Maintain Foregut Progenitors and Induce szl(A) Strategy to identify genes induced in the foregut progenitors (fg; green) by the precardiac mesoderm (cm; red).(B) BMP and FGF pathway genes identified by microarray.(C) In situ hybridization to bisected stage 20 embryos (anterior left) and isolated ventral explants cultured from stage 15 to 23 with or without mesoderm confirms that szl and hhex expression requires mesodermal signals. Injection of cont-MO, bmp2-MO, or BMP2 protein demonstrates that szl and hhex expression are regulated by BMP signaling.(D) Bisected stage 20 embryos (anterior left) showing bmp2, bmp4, and bmp7 expression in the precardiac (cm) and the ventral lateral plate mesoderm (lpm).See also Figure S1. Image published in: Kenny AP et al. (2012) Copyright © 2012. Image reproduced with permission of the Publisher, Elsevier B. V. Experiment + Assay Source Phenotypes and Disease Xla Wt + bmp2 MO + NF18-20 (in situ hybridization) fig.1.c Expression Phenotype decreased amount hhex.L expression in foregut endoderm decreased amount szl.L expression in foregut endoderm Xla Wt + Hsa.BMP2 + NF18-20 (in situ hybridization) fig.1.c Expression Phenotype increased amount hhex.L expression in foregut endoderm increased amount szl.L expression in foregut endoderm Xla Wt + Hsa.BMP2 + NF20 (in situ hybridization) fig.1.c Expression Phenotype increased amount hhex.L expression in foregut endoderm increased amount szl.L expression in foregut endoderm Larger Image Printer Friendly View

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