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Figure 6. Knockdown of Tll Proteases Rescues the szl-MO Phenotype(A) Expression of szl, tll1, bmp1, and chordin in stage 18 embryos.(E) tll1 expression in embryos injected in the C1/D1 cells with control-MO (20 ng), szl-MO (15 ng), bmp2-MO (20 ng) or treated with BMP-receptor inhibitor LDN193189 (40 μM).(I) Knockdown of Tll1 and Bmp1 rescues the Szl morphant phenotype. tll1-MOs and bmp1-MOs (15 ng each) were injected into C1/D1 cells with or without szl-MO (15 ng) and assayed for hhex (I) and vent1/2 (M) at stage 20 and the liver marker for1 at stage 35 (Q).See also Figure S4. Image published in: Kenny AP et al. (2012) Copyright © 2012. Image reproduced with permission of the Publisher, Elsevier B. V. Experiment + Assay Source Phenotypes and Disease Xla Wt + LDN-193189 + NF18 (in situ hybridization) fig.6.h Expression Phenotype decreased amount tll1.L expression in alimentary system Xla Wt + szl MO + NF20 (in situ hybridization) fig.6.j Expression Phenotype decreased amount hhex.L expression in foregut Xla Wt + szl MO + NF20 (in situ hybridization) fig.6.n Expression Phenotype decreased amount ventx1.2.L expression in foregut decreased amount ventx2.1.L expression in foregut Xla Wt + szl MO + NF35/36 (in situ hybridization) fig.6.r Expression Phenotype decreased amount nr1h5.L expression in liver Larger Image Printer Friendly View

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