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Figure S2. Targeted injection of the szl-MO into the foregut does not disrupt gastrula axial pattering. (D) Expression of hhex at stage 32 and nkx2.1 in the lung buds of stage 42 isolated gut tubes shows that embryos injected with the szl-MO (20 ng) lack foregut organs and this can be rescued by sequential injection of the szl-MO and a szl expression plasmid (500 pg). Image published in: Kenny AP et al. (2012) Copyright © 2012. Image reproduced with permission of the Publisher, Elsevier B. V. Experiment + Assay Source Phenotypes and Disease Xla Wt + szl MO + NF32 (in situ hybridization) fig.S2.d Expression Phenotype decreased amount hhex.L expression in lung primordium decreased amount nkx2-1.L expression in lung primordium Xla Wt + szl MO + NF32 (morphology) fig.S2.d Anatomical Phenotype abnormally ruffled dorsal fin absent lung primordium decreased size of the head Larger Image Printer Friendly View

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