Xenbase Image ID: 81451

Figure 3. xSuv4-20h enzymes are required for differentiation of the neuroectoderm. (A) Schematic illustration of analysed markers of the different germ layers (germ layer colour code extended to in situ panels). Downregulated genes upon xSuv4-20h depletion are labelled in red. (B) Expression pattern of the neuroectodermal markers Ngnr 1a (NF12.5), Delta-like 1 (NF13), and N-tubulin (NF15). The pictures show dorsal views of the open neural plate with anterior to the left. (C) Expression patterns of XK81 (ectoderm), Sox2, Xiro1, Zic1 (neuroectoderm), Xbra, MyoD (mesoderm), Sox17 α, Endodermin (endoderm) in ctrl-MO injected or double morphant embryos. XK81 - anterior views with dorsal side to the top. Sox2 and MyoD - dorsal views, anterior to the left. Xiro1 and Zic1 - dorsal views; injected halves are lineage-traced by coinjection of LacZ mRNA and subsequent βal staining (light blue). Xbra - vegetal view. Sox-17 α - internal stain from the injected side in bisected embryos, animal pole up. Endodermin internal stain from the injected side in bisected embryos; anterior to the left. doi:10.1371/journal.pgen.1003188.g003 Image published in: Nicetto D et al. (2013) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Gene Synonyms Species Stage(s) Tissue neurog2.L atoh4, neurog2-a, neurog2-b, neurogenin 2, neurogenin-2, neurogenin-related-1, neurogenin2, ngn-2, ngn2, ngnr, ngnr 1a, Ngnr-1, Ngnr1, X-ngnr-1, xngn2, Xngnr-1, XNgnr1 X. laevis Throughout NF stage 12.5 neuroectoderm dll1.L delta-1, Delta-1, delta1, x-delta, X-delta-1, Xdelta-1, Xdelta1, XDelta1 X. laevis Throughout NF stage 13 neuroectoderm neural plate tubb2b.L N-Tub, n-tubulin, NBT, neural beta-tubulin, NST, ntubulin, Xn-tubulin X. laevis Throughout NF stage 15 neuroectoderm neural plate neural plate border neural tube Rohon-Beard neuron interneuron neural progenitor cell krt12.4.L ck81, cytok, cytokeratin, E-keratin, epi-keratin, epidermal keratin, Epidermis-specific keratin, EpiK, epiker, EpK, epK, K81, xK81, xk81a, xk81a1 X. laevis Throughout NF stage 15 non-neural ectoderm anterior neural ridge sox2.S anop3, LOC108718087, mcops3, Sox-2, XLSOX-2, Xsox-2, XSox2 X. laevis Sometime during NF stage 15 to NF stage 16 neural plate neuroectoderm irx1.L iro, irx1-a, irx1-b, Xiro, Xiro1 X. laevis Throughout NF stage 11 neuroectoderm zic1.L odd-paired-like, opl, Zic-r1, Zic-related-1 X. laevis Throughout NF stage 11 neuroectoderm tbxt.L bra, brachyury, ntl, t, t-a, t-b, X-bra, Xbra, Xbrachyury X. laevis Throughout NF stage 11 mesoderm marginal zone myod1.L mf25, MyoD, myod1-a, myod1-b, myogenic factor 3, XMyoD, XtmyoD X. laevis Throughout NF stage 15 presomitic mesoderm paraxial mesoderm sox17a.L sox17 alpha, sox17-alpha, Sox17alpha, tSox17alpha, xsox17, Xsox17-alpha, xsox17a, Xsox17alpha, xSox17alpha1, xSox17alpha2 X. laevis Throughout NF stage 15 endoderm central endoderm a2m.S A2Moo, Alpha2-macroglobulin, edd, endod, endodermin, LOC108695707, ovomacroglobulin X. laevis Throughout NF stage 15 endoderm Image source: Published Larger Image Printer Friendly View

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