Xenbase Image ID: 81552

Figure 3. Specificity of 2′-O-methyl oligos against β-catenin. (a) Phenotypes of uninjected embryos (stage 17); 20/20, 100% normal phenotype. (b) Phenotypes of embryos injected with 6 ng β-cat-2ome oligo; 15/15, 100% axis deficiency. (c) Phenotypes of embryos coinjected with 6 ng β-cat-2ome oligo and 50 pg β-catenin mRNA (dorsal injection); 3/15, 20% axis deficiency. (d) Quantitative real-time PCR of dorsal and ventral markers in control (Un) and oligo-injected embryos at stage 10.25. (e) Quantitative real-time PCR of anterodorsal (otx2, myod) and ventroposterior (szl, evx1) markers in control (Un) and oligo-injected embryos at stage 14. Reproduced with permission of the Publisher, John Wiley & Sons. Image published in: Schneider PN et al. (2011) Copyright © 2011. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View

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