Xenbase Image ID: 81553

Figure 4. 2′-O-methyl oligos against Xenopus wnt11 and bmp4 cause pronephric and tail fin/proctodeal defects. (a) pax8 expression in an uninjected control embryo (stage 24/25); 20/20, 100% normal expression (one experiments). (b) pax8 expression in embryos injected unilaterally with 20 ng of wnt11-MO; 5/9, 56% reduced pronephros (one experiment). (c) pax8 expression in embryos injected unilaterally with 6 ng of wnt11-2ome; 6/8, 75% reduced pronephros (one experiment). (d) Phenotypes of uninjected embryos (stage 36/7); 40/40, 100% normal phenotype (two experiments). (e) Phenotypes of embryos injected with 4ng bmp4-2ome oligo. Arrows indicate ventral tail fin (solid line) and proctodeal (dashed line) abnormalities; 16/28, 57% tail defects (two experiments). Reproduced with permission of the Publisher, John Wiley & Sons. Image published in: Schneider PN et al. (2011) Copyright © 2011. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View

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