Xenbase Image ID: 81567

Figure 2. The differentiation of Xenopus ciliated epithelium. A: Ciliated cell and ionocyte precursors reside in a sublayer of the epidermis at Stage 17 and undergo radial intercalation to join the outer epidermis by Stage 25. B: Regulation of cell fate in the skin of Xenopus. Inhibition of the Notch pathway leads to an increase in ciliated cell and ionocyte differentiation. Activation of the Notch pathway, by silencing miR449 for example, leads to a severe decrease in ciliated cells. Ectopic expression of FoxJ1 leads to outer epithelial cells that are capable of generating 1-2 motile cilia. Ectopic expression of FoxI1 leads to an increase in ionocytes. Reproduced with permission of the Publisher, John Wiley & Sons Image published in: Werner ME and Mitchell BJ (2012) Copyright © 2012. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View

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