Xenbase Image ID: 81593

Figure 2. Activation of FGFR2 Signaling Increases the Size of the Neural Tube and Changes Retinal Fates to Ventral Neural Fates(A and B) Neural tube is thicker on the cFGFR2-injected side (*). os, expanded optic stalk.(C) White lines indicate extent of sox3 expression on control (right) and cFGFR2-injected (*) sides of neural plate.(D) D1.1.1 clone (green) in stage 14 forebrain region of control. Arrow denotes midline.(E) D1.1.1 clone (green) in the same region of cFGFR2-injected embryo.(F) Expanded neural tube on cFGFR2-injected side (*). Brown stain indicates HNK-1 expression.(G) Expression of cFGFR2 in D1.1.1 clone (red) expands pax2 expression on the injected side (*) of neural plate.(H) Expression of cFGFR2 in D1.1.1 expands forebrain pax2 expression (white bracket) on the injected side (inj) of tail bud embryos. un, uninjected.(I) Number of dopamine cells in the hypothalamus of cFGFR2-injected embryos. *, p < 0.001.(J) The lengths of dorsal (black line) and ventral (Nkx2.4+; white line) forebrain domains in cFGFR2-injected and wild-type (wt) embryos. Image published in: Moore KB et al. (2004) Copyright © 2004. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue sox3.S Sry, Xlsox3, xSox3, Xtsox3 X. laevis Throughout NF stage 17 neural plate border neural fold pax2.L LOC108697493, pax-2, pax2-a, pax2-b, XPax-2, XPax2 X. laevis Throughout NF stage 28 forebrain otic vesicle midbrain-hindbrain boundary pax2.L LOC108697493, pax-2, pax2-a, pax2-b, XPax-2, XPax2 X. laevis Throughout NF stage 15 presumptive midbrain-hindbrain boundary Image source: Published Larger Image Printer Friendly View

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