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Fig. S9. Scheme illustrating the circuits from which the head-inducing network is assembled. (1) Positive feedback in Nodal expression. (2) Negative feedback between Nodal and Nodal antagonists (1). (3) As described in this paper, Nodal antagonists facilitate ADMP signaling that, in turn, negative feedbacks on their expression, all together establishing a self-regulating loop. Red lines indicate the extracellular regulations, whereas black lines stand for transcriptional regulations. Image published in: Inui M et al. (2012) Copyright © 2012. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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