Xenbase Image ID: 82317

Figure3. Treatment with Low-Dose Noc Specifically Disrupts Astral Microtubules and Causes Spindles to Reposition Apically(A) Spindles in control (Ctrl) versus Noc-treated embryos; treatment with Noc eradicates astral microtubules that are seen in Ctrl spindles and causes spindles to move to the apical cell surface.(B) Stills taken from Movie S3, showing spindles in Ctrl and Noc-treated embryos. The Noc-treated spindle moves toward the apical cell surface, whereas the Ctrl spindle remains in a constant position along the apicobasal axis even as anaphase proceeds.Scale bars represent 10m. See also FigureS1 and Movies S3 and S4. Image published in: Woolner S and Papalopulu N (2012) © 2012 ELL & Excerpta Medica. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Experiment + Assay Source Phenotypes and Disease Xla Wt + nocodazole + NF10-10.5 (immunohistochemistry) fig.3.a Anatomical Phenotype absent astral microtubule Xla Wt + nocodazole + NF10-10.5 (immunohistochemistry) fig.3.b Anatomical Phenotype abnormally localised mitotic spindle Larger Image Printer Friendly View

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