Xenbase Image ID: 82541

Fig. 6. Sites complementary to microRNAs miR-125 and let-7 in human and mouse Lin-28. Top, a schematic of the Lin-28 mRNA. The ORF is in gray. The numbers above the line indicate the positions of the start codon, stop codon, and poly(A) tail, respectively. The black boxes indicate regions of high sequence identity between mouse and human 3 UTRs; the lengths and percent identity of each of these regions is indicated below the schematic. The black boxes above the schematic indicate 3 UTR sequences of at least 40 nt having greater than 95% identity between mouse and human. The positions of the potential miR-125 and let-7 complementary sites are indicated by arrows. Bottom, possible secondary structures formed between the UTR and microRNAs. Image published in: Moss EG and Tang L (2003) Copyright © 2003. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

Return to previous page