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Figure 11. The First 32 Members of the Bent Axis Phenotypic Class This class can be subdivided into five synphenotype groups, as indicated in Figure 3 and Table 4. All embryos are shown at the tadpole stage (stage 35�41). doi:10.1371/journal.pgen.0020193.g011 Image published in: Rana AA et al. (2006) Copyright © 2006. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Experiment + Assay Source Phenotypes and Disease Xtr Wt + acbd6 MO + NF10.5 (morphology) fig.11 Anatomical Phenotype abnormal gastrulation Xtr Wt + acbd6 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + acbd6 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal eye morphology decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + ap1m2 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype decreased length of anterior-posterior axis Xtr Wt + ap1m2 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal tail morphology decreased length of anterior-posterior axis Xtr Wt + arid4a MO + NF10.5 (morphology) fig.11 Anatomical Phenotype abnormal development of blastopore abnormal gastrulation Xtr Wt + arid4a MO + tailbud stage (morphology) fig.11 Anatomical Phenotype decreased length of anterior-posterior axis decreased size of the head wholly ventralized embryo Xtr Wt + arid4a MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal head morphology abnormal ventral trunk morphology decreased size of the tail Xtr Wt + c19orf52 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype decreased length of anterior-posterior axis Xtr Wt + c19orf52 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal tail morphology decreased length of anterior-posterior axis Xtr Wt + ccdc174 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal tail morphology Xtr Wt + ccz1b + tailbud stage (morphology) fig.11 Anatomical Phenotype decreased length of anterior-posterior axis Xtr Wt + ccz1b + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal heart morphology decreased length of anterior-posterior axis decreased size of the head Xtr Wt + celsr1 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal alimentary system abnormal bending of anterior-posterior axis abnormal bending of tail abnormal ventral trunk morphology decreased length of anterior-posterior axis decreased length of tail Xtr Wt + dnal1 MO + NF10-10.5 (morphology) fig.11 Anatomical Phenotype abnormal gastrulation Xtr Wt + dnal1 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail decreased length of tail Xtr Wt + dnal1 MO + tadpole stage (whole-mount microscopy) fig.11 Anatomical Phenotype abnormal swimming behavior Xtr Wt + dock7 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype abnormal development of embryo Xtr Wt + dock7 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal head morphology abnormal somite morphology abnormal tail morphology abnormal ventral trunk morphology decreased length of anterior-posterior axis tail abnormally curved dorsally Xtr Wt + dync1i2 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + dync1i2 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal heart morphology abnormal tail morphology abnormal trunk morphology decreased size of the head Xtr Wt + dync2h1 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal tail morphology Xtr Wt + dync2h1 MO + tadpole stage (whole-mount microscopy) fig.11 Anatomical Phenotype absent swimming behavior Xtr Wt + dynlt1 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype abnormal development of embryo Xtr Wt + dynlt1 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal development of embryo abnormal tail morphology Xtr Wt + fgfr4 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype abnormal development of embryo Xtr Wt + fgfr4 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype abnormal development of embryo Xtr Wt + fgfr4 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal tail morphology decreased length of tail decreased size of the head Xtr Wt + fgfr4 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal tail morphology decreased length of tail decreased size of the head Xtr Wt + fzd2 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal heart decreased length of anterior-posterior axis decreased length of tail edematous ventral trunk Xtr Wt + fzd7 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype decreased length of anterior-posterior axis decreased size of the tail Xtr Wt + fzd7 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal tail morphology decreased length of tail Xtr Wt + mark2 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype abnormal development of embryo decreased length of anterior-posterior axis Xtr Wt + mark2 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail decreased length of anterior-posterior axis decreased size of the eye wholly ventralized embryo Xtr Wt + msx1 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype abnormal tail morphology Xtr Wt + msx1 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal tail morphology Xtr Wt + msx1 MO + tadpole stage (whole-mount microscopy) fig.11 Anatomical Phenotype abnormal swimming behavior Xtr Wt + nipbl MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail decreased length of anterior-posterior axis decreased length of tail Xtr Wt + reep4 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype decreased length of anterior-posterior axis Xtr Wt + reep4 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal somitogenesis decreased length of anterior-posterior axis edematous ventral trunk Xtr Wt + skida1 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype abnormal development of embryo decreased length of anterior-posterior axis Xtr Wt + skida1 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal branchial arch morphology abnormal development of eye abnormal development of head abnormal development of neural tube abnormal tail morphology decreased size of the eye decreased size of the head obsolete abnormally edematous head Xtr Wt + smad2 MO + NF10.5 (morphology) fig.11 Anatomical Phenotype abnormal gastrulation Xtr Wt + smad2 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype abnormal axis elongation decreased length of anterior-posterior axis Xtr Wt + smad2 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal development of embryo abnormal tail morphology decreased length of tail decreased size of the tail Xtr Wt + smad6 MO + NF10.25 (morphology) fig.11 Anatomical Phenotype abnormal development of embryo Xtr Wt + smad6 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype abnormal development of embryo Xtr Wt + smad6 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype decreased length of anterior-posterior axis Xtr Wt + smad9 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype abnormal development of embryo Xtr Wt + smad9 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal development of embryo abnormal tail morphology decreased length of tail Xtr Wt + spice1 MO + NF10.5 (morphology) fig.11 Anatomical Phenotype abnormal gastrulation Xtr Wt + spice1 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype abnormal development of embryo Xtr Wt + spice1 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal tail morphology Xtr Wt + suv420h1 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype abnormal development of embryo abnormal ventral trunk morphology decreased length of anterior-posterior axis decreased length of tail Xtr Wt + tbx3 MO + NF10.5 (morphology) fig.11 Anatomical Phenotype abnormal gastrulation Xtr Wt + tbx3 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal tail morphology Xtr Wt + tbx6 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype abnormal anterior-posterior axis morphology wholly ventralized embryo Xtr Wt + tbx6 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal anterior-posterior axis morphology decreased length of tail obsolete abnormally edematous pericardium tail abnormally curved dorsally Xtr Wt + tgif1 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype abnormal development of embryo Xtr Wt + tgif1 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal tail morphology edematous ventral trunk Xtr Wt + vegt MO + NF10.5 (morphology) fig.11 Anatomical Phenotype abnormal gastrulation Xtr Wt + vegt MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal alimentary system morphology abnormal bending of tail abnormal eye morphology abnormal ventral trunk morphology decreased length of anterior-posterior axis decreased size of the tail wholly ventralized embryo Xtr Wt + zmynd11 MO + tailbud stage (morphology) fig.11 Anatomical Phenotype decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + zmynd11 MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of anterior-posterior axis abnormal bending of tail decreased length of anterior-posterior axis edematous ventral trunk Xtr Wt + zufsp MO + NF10.5 (morphology) fig.11 Anatomical Phenotype abnormal gastrulation Xtr Wt + zufsp MO + tailbud stage (morphology) fig.11 Anatomical Phenotype abnormal axis elongation decreased length of anterior-posterior axis Xtr Wt + zufsp MO + tadpole stage (morphology) fig.11 Anatomical Phenotype abnormal bending of tail abnormal tail morphology Larger Image Printer Friendly View

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