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Figure 12. The Final 31 Members of the Bent Axis Phenotypic Class This class can be subdivided into five synphenotype groups, as indicated in Figure 3 and Table 4. All embryos are shown at the tadpole stage (stage 35�41). doi:10.1371/journal.pgen.0020193.g012 Image published in: Rana AA et al. (2006) Copyright © 2006. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Experiment + Assay Source Phenotypes and Disease Xtr Wt + aurka MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal bending of anterior-posterior axis Xtr Wt + c1orf131 MO + NF10-10.5 (morphology) fig.12 Anatomical Phenotype abnormal gastrulation Xtr Wt + c1orf131 MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal bending of anterior-posterior axis abnormally ventrally curved tail decreased size of the tail decreased size of the trunk edematous ventral trunk Xtr Wt + calhm2 MO + NF10-10.5 (morphology) fig.12 Anatomical Phenotype abnormal gastrulation Xtr Wt + calhm2 MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal bending of anterior-posterior axis abnormal development of embryo abnormally ventrally curved tail Xtr Wt + calhm2 MO + tadpole stage (whole-mount microscopy) fig.12 Anatomical Phenotype abnormal swimming behavior Xtr Wt + cdk2ap2 MO + tailbud stage (morphology) fig.12 Anatomical Phenotype abnormal development of embryo Xtr Wt + cdk2ap2 MO + tailbud stage (morphology) fig.12 Anatomical Phenotype abnormal development of neural tube abnormal gastrulation decreased length of anterior-posterior axis Xtr Wt + cdk2ap2 MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal bending of tail abnormal head morphology decreased length of anterior-posterior axis decreased size of the tail edematous ventral trunk Xtr Wt + cep295 or kiaa1731 MO + tailbud stage (morphology) fig.12 Anatomical Phenotype abnormal development of embryo Xtr Wt + cep295 or kiaa1731 MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal bending of tail abnormal head morphology abnormal somite morphology abnormal tail morphology abnormal ventral trunk morphology decreased length of anterior-posterior axis Xtr Wt + dnal4 MO + NF10-10.5 (morphology) fig.12 Anatomical Phenotype abnormal gastrulation Xtr Wt + dnal4 MO + tailbud stage (morphology) fig.12 Anatomical Phenotype decreased length of anterior-posterior axis Xtr Wt + dnal4 MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal bending of tail abnormal development of heart abnormal heart morphology decreased length of anterior-posterior axis Xtr Wt + dync1li1 MO + NF10-10.5 (morphology) fig.12 Anatomical Phenotype abnormal gastrulation Xtr Wt + dync1li1 MO + tailbud stage (morphology) fig.12 Anatomical Phenotype decreased length of anterior-posterior axis Xtr Wt + dync1li1 MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal bending of tail abnormal development of embryo decreased length of anterior-posterior axis Xtr Wt + eed MO + tailbud stage (morphology) fig.12 Anatomical Phenotype abnormally anterioralized embryo decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + eed MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal eye morphology decreased length of anterior-posterior axis tail abnormally curved dorsally Xtr Wt + fgfr3 MO + tailbud stage (morphology) fig.12 Anatomical Phenotype abnormal development of embryo abnormally anterioralized embryo Xtr Wt + fgfr3 MO + tailbud stage (morphology) fig.12 Anatomical Phenotype abnormal development of embryo abnormally anterioralized embryo Xtr Wt + fgfr3 MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal tadpole morphology tail abnormally curved dorsally Xtr Wt + fgfr3 MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal tadpole morphology decreased length of anterior-posterior axis decreased size of the head tail abnormally curved dorsally Xtr Wt + heatr5b MO + tailbud stage (morphology) fig.12 Anatomical Phenotype decreased length of anterior-posterior axis Xtr Wt + heatr5b MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal anterior-posterior axis, curved dorsal decreased length of anterior-posterior axis decreased size of the tail increased apoptosis in embryo tail abnormally curved dorsally Xtr Wt + heatr5b MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal bending of anterior-posterior axis abnormally ventrally curved tail increased apoptosis in embryo Xtr Wt + lefty MO + tailbud stage (morphology) fig.12 Anatomical Phenotype decreased length of anterior-posterior axis Xtr Wt + lefty MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal bending of anterior-posterior axis abnormal development of embryo abnormally ventrally curved tail Xtr Wt + mfge8 MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal bending of anterior-posterior axis abnormally ventrally curved tail Xtr Wt + myo18b MO + tailbud stage (morphology) fig.12 Anatomical Phenotype abnormal development of embryo Xtr Wt + nodal3.1 MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal head morphology abnormal tadpole morphology abnormal ventral trunk morphology decreased length of anterior-posterior axis decreased length of tail tail abnormally curved dorsally Xtr Wt + pard3b MO + NF10.5-11.5 (morphology) fig.12 Anatomical Phenotype abnormal gastrulation Xtr Wt + pard3b MO + tailbud stage (morphology) fig.12 Anatomical Phenotype decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + pard3b MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis tail abnormally curved dorsally Xtr Wt + pard6g MO + tailbud stage (morphology) fig.12 Anatomical Phenotype decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + pard6g MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal head morphology abnormally ventrally curved tail decreased size of the tail increased size of the ventral trunk Xtr Wt + pced1a MO + tailbud stage (morphology) fig.12 Anatomical Phenotype abnormal bending of anterior-posterior axis abnormal development of embryo Xtr Wt + pced1a MO + tailbud stage (morphology) fig.12 Anatomical Phenotype abnormal development of embryo Xtr Wt + pced1a MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal bending of tail abnormal head morphology abnormal somite morphology tail abnormally curved dorsally Xtr Wt + pced1a MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormally ventrally curved tail Xtr Wt + pdss2 MO + gastrula stage-tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal development of embryo abnormal gastrulation Xtr Wt + pdss2 MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal anterior-posterior axis, curved dorsal decreased length of anterior-posterior axis decreased length of tail Xtr Wt + rnf112 MO + gastrula stage (morphology) fig.12 Anatomical Phenotype abnormal gastrulation Xtr Wt + rnf112 MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal dorsal trunk morphology abnormal head morphology abnormal tadpole morphology decreased length of anterior-posterior axis Xtr Wt + rxrb MO + tailbud stage (morphology) fig.12 Anatomical Phenotype abnormal development of embryo abnormally anterioralized embryo Xtr Wt + rxrb MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal bending of anterior-posterior axis decreased length of anterior-posterior axis decreased length of tail tail abnormally curved dorsally Xtr Wt + serpina3 MO + NF10-10.5 (morphology) fig.12 Anatomical Phenotype abnormal gastrulation Xtr Wt + serpina3 MO + tailbud stage (morphology) fig.12 Anatomical Phenotype decreased length of anterior-posterior axis Xtr Wt + serpina3 MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal anterior-posterior axis, curved dorsal decreased length of anterior-posterior axis decreased length of tail Xtr Wt + smad4.2 MO + tailbud stage (morphology) fig.12 Anatomical Phenotype abnormal development of head abnormal development of tail decreased length of anterior-posterior axis Xtr Wt + smad4.2 MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal development of embryo abnormal ventral trunk morphology abnormally ventrally curved tail decreased length of anterior-posterior axis decreased length of tail Xtr Wt + st13 MO + tailbud stage (morphology) fig.12 Anatomical Phenotype decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + st13 MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal development of embryo abnormal tadpole morphology decreased length of anterior-posterior axis decreased length of tail decreased size of the ventral trunk tail abnormally curved dorsally Xtr Wt + sugt1 MO + NF10-10.5 (morphology) fig.12 Anatomical Phenotype abnormal gastrulation Xtr Wt + sugt1 MO + tailbud stage (morphology) fig.12 Anatomical Phenotype abnormal head morphology abnormal tail bud morphology decreased length of anterior-posterior axis decreased length of tail decreased size of the whole organism tail abnormally curved dorsally Xtr Wt + sugt1 MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal axis elongation decreased length of anterior-posterior axis decreased length of tail tail abnormally curved dorsally Xtr Wt + wdr74 MO + NF10-10.5 (morphology) fig.12 Anatomical Phenotype abnormal gastrulation Xtr Wt + wnt5b MO + tailbud stage (morphology) fig.12 Anatomical Phenotype decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + wnt5b MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal bending of anterior-posterior axis abnormally ventrally curved tail decreased length of anterior-posterior axis edematous ventral trunk Xtr Wt + ywhab MO + NF10-10.5 (morphology) fig.12 Anatomical Phenotype abnormal gastrulation Xtr Wt + ywhab MO + tailbud stage (morphology) fig.12 Anatomical Phenotype decreased length of anterior-posterior axis Xtr Wt + ywhab MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal bending of anterior-posterior axis abnormally ventrally curved tail decreased size of the head Xtr Wt + znf674 MO + tadpole stage (morphology) fig.12 Anatomical Phenotype abnormal bending of anterior-posterior axis abnormally decreased number of melanophore abnormally ventrally curved tail decreased size of the head Larger Image Printer Friendly View

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