Xenbase Image ID: 83162

Figure 4. Knockdown of Gli1 or Gli2 rescues phenotypes induced by partial depletion of Dzip1. (A) Whole mount in situ hybridization of ptc1 (top), pax6 (middle) and pax2 (bottom) in controls and embryos either receiving a single injection of Gli1 MO, Gli2 MO, or DMO, and double knockdown embryos injected with Gli1 MO/DMO or Gli2 MO/DMO. In the middle panels, the distance between the floor plate and the ventral border of the pax6 expression domain was highlighted. (B-D) Summary of ptc1 expression phenotypes (B), pax6 expression phenotypes (C) or pax2 expression phenotypes (D) in controls and the different groups of embryos receiving either a single or double morpholino injection against Gli1, Gli2 or Dzip1. Image published in: Schwend T et al. (2013) Copyright © 2013. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue ptch1.S patched, patched1, Ptc-1, Ptc1, X-ptc1, XPtc1 X. laevis Throughout NF stage 35 and 36 somite spinal cord pax6.L an2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6 X. laevis Throughout NF stage 35 and 36 spinal cord pax2.L LOC108697493, pax-2, pax2-a, pax2-b, XPax-2, XPax2 X. laevis Throughout NF stage 35 and 36 eye optic stalk Image source: Published Larger Image Printer Friendly View

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