Xenbase Image ID: 83320

Fig. 5. Dazap2 gain-of-function expands the neural plate and induces a posterior identity at the expense of anterior fates. Injections of dazap2 mRNA were targeted either dorsally (A′-H′, red arrow) or ventrally (A′-E′, green arrow). Embryos were analyzed at stages 16-18 (shown in dorsal views with anterior at the top (A-E′), or frontal views (F-H′)). The injected side is on the right, injected cells are marked by the red nuclear stain. General neural markers nrp1 (A-A′), sox2 (B-B′) and sox11 (C-C′) are expanded when Dazap2 is expressed in or around the neural plate but not when dazap2 is injected on the ventral side of the embryo. MyoD (D-D′) expression is not affected by either dorsal or ventral injections. Hoxb9 (E-E′) is strongly ectopically expressed in dorsal but not ventral targeted injections. The expression of anterior neural markers cpl1 (F, F′) and pax6 (G, G′) is decreased when dazap2 is targeted to the anterior neural plate (arrows, bar indicates the midline). Image published in: Roche DD et al. (2009) Copyright © 2009. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue nrp1.L A5 antigen, LOC108718763, neuropilin, neuropilin-1, np-1, npn-1, nrp, nrp-1, pNPG152 X. laevis Sometime during NF stage 16 to NF stage 18 neuroectoderm neural plate anterior neural ridge sox2.L anop3, LOC108718087, mcops3, Sox-2, XLSOX-2, Xsox-2, XSox2 X. laevis Sometime during NF stage 16 to NF stage 18 neuroectoderm neural plate preplacodal ectoderm anterior placodal area sox11.L sox11-a, sox11-b, XLS13, xls13a, XLS13b, xSOX-11, xsox11 X. laevis Sometime during NF stage 16 to NF stage 18 neuroectoderm neural plate neural fold myod1.S mf25, MyoD, myod1-a, myod1-b, myogenic factor 3, XMyoD, XtmyoD X. laevis Sometime during NF stage 16 to NF stage 18 paraxial mesoderm hoxc9-like.L X. laevis Sometime during NF stage 16 to NF stage 18 neural fold ptgds.S cerebrin-28, cpl-1, cpl1, l-pgds, lipocalin, lpgds, pds, pgd2, pgds, pgds2, ptgds-a, ptgds-b, XlCpl1 X. laevis Sometime during NF stage 16 to NF stage 18 anterior neural ridge pax6.L an2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6 X. laevis Sometime during NF stage 16 to NF stage 18 eye primordium neural fold Image source: Published Larger Image Printer Friendly View

Return to previous page