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Fig. 8. Dazap2 activity is Cdx4-independent. mRNAs for dazap2 (250 pg, B), cdx-EnR (250 pg, C) or a combination of dazap2 and cdx-EnR (250 pg each, D) were injected into one cell of 4-cell stage embryos (all were co-injected with lacZ mRNA). Stage 18 embryos are shown in dorsal views, with anterior at the top. Dazap2 injections induce ectopic hoxb9 expression (B, arrowhead) while cdx4-EnR overexpression blocks hoxb9 induction (C, arrow). Combined Dazap2 and cdx-EnR injection results in robust hoxb9 induction (D, arrowhead). Parallel experiments in explants (E) show that Dazap2 induces hoxb9 either alone (lane 4) or in the presence of Cdx-EnR (lane 5). Image published in: Roche DD et al. (2009) Copyright © 2009. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue hoxc9-like.L X. laevis Throughout NF stage 18 neural fold Image source: Published Larger Image Printer Friendly View

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