Xenbase Image ID: 83514

Fig. 3. Common morphologies of differentiated hearts from embryos treated with retinoic acid antagonists. When viewed from the ventral side, control embryos stained for αMHC expression by whole-mount in situ hybridization show a heart tube that is initiating the normal looping process (A). The most severe phenotype observed with AGN 194301 treatment was a lack of both tube formation and a ventral gap in the αMHC expression domain indicating a lack of fusion of the two heart primordia (B). Embryos that showed a fusion of the heart primordia at the ventral midline but still no tube formation (C) were seen with lower doses of antagonist. At even lower doses of antagonist, the most common heart phenotype observed was an apparent heart tube that appeared to not undergo looping at this stage (D). Image published in: Collop AH et al. (2006) Copyright © 2006. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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