Xenbase Image ID: 83857

Fig. 5. The effects of modulated retinoid signaling on expression pattern of retinoic acid receptor (RAR) target genes. The effects of AGN 193109, TTNPB, or vehicle control on expression pattern of three expressed sequence tags (ESTs), XL016p20 (S1�S6), XL049b08 (T1�T6), and XL043c08 (U1�U6), were determined in stage 18 embryos by whole-mount in situ hybridization. AGN193109 treatment reduced posterior neural expression of all three genes compared with controls (S1 vs. S2, T1 vs. T2, and U1 vs. U2) but increased medial staining of XL016p20 (S1 vs. S2), XL049b08 staining in the eye anlagen (T4 vs. T5), and XL043C08 expression in the forebrain (U1 vs. U2). In contrast, TTNPB treatment increased expression of XL016P20 throughout the embryo (S3, S6 vs. S2, S5) and reduced Xl043C08 staining in the forebrain and presumptive trigeminal ganglion (U3, U6 vs. U2, U5). S1�S3, T1�T3, and U1�U3: dorsal view; S4�S6, T4�T6, and U4�U6: anterior view; TTNPB, TTNPB-treated embryos; Control, vehicle control embryo; AGN193109, AGN193109-treated embryos. Image published in: Arima K et al. (2005) Copyright © 2005. Image reproduced with permission of the Publisher, John Wiley & Sons. Gene Synonyms Species Stage(s) Tissue gse1.S X. laevis Throughout NF stage 18 neural plate pre-chordal neural plate chordal neural plate branchial crest preplacodal ectoderm mxi1.L mxi, xmxi1 X. laevis Throughout NF stage 18 chordal neural plate stomodeal-hypophyseal primordium neural plate cranial placode pkdcc.2.S pkdcc2, sgk493, vlk X. laevis Throughout NF stage 18 cardiac mesoderm neural plate chordal neural plate cranial placode Image source: Published Larger Image Printer Friendly View

Return to previous page