Xenbase Image ID: 83949

Fig. 11. Par3 controls CIL by inhibiting Trio/Rac and promoting microtubule catastrophe at cell-cell contacts. (A) CIL is required during NC development for directional and collective cell migration. (B) Rac1-Trio activation in the lamellipodia of migrating cells, promoting microtubule stability. (C) Upon contact, Par3 and other proteins such as N-cadherin are localised to the cell-cell contact. Par3 sequestration of Trio at the cell-cell contact to inhibits Rac1-Trio, leading to microtubule catastrophe. Rac1-Trio activation is biased toward another part of the cell, promoting microtubule stability and lamellipodia extension there. (D) The change in Rho-GTPase activity alters cell polarity. A new lamellipodium develops and the cell changes its direction of migration to move away from the contact, completing the process of CIL. (E) Activation of Par3 at the cell contact leads to microtubule depolymerisation. (F) In the absence of Par3, Trio and Rac remain active and microtubule catastrophe is impaired at the cell contact. Image published in: Moore R et al. (2013) Copyright © 2013. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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