Xenbase Image ID: 84159

Figure 6. miR-142-3p Restricts Inhibitory TGFb Signaling and Forms a Double-Negative Gate, Thereby Controlling the Initiation of the Hemangioblast Program (A) Alignments of the target sites in tgfbr1, acvr2a, and acvr1b (blue) with miR-142-3p miRNA (red). (B) WISH analysis at stages 25–26 showing that tgfbr1 expression is elevated in the DLP region (arrows) in miR-142-3p morphants. (C) Schematic diagram summarizing the rescue experiments performed with the TGFb type I receptor kinase inhibitors, SB431542 and LY2157299, in miR-142-3p morphants. Image published in: Nimmo R et al. (2013) Copyright © 2013. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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