Xenbase Image ID: 85127

Fig. 6. The non-cell-autonomous effects of Smad7 are not mediated by the Wnt/β-catenin or the FGF pathways. When co-injected with the Wnt/β-catenin inhibitor GSK3, Smad7 still induces Sox3 (A–B), Sox2 (C–D) and Chordin (E–F). The same result is obtained when Smad7-injected embryos are grown in the presence of the FGF inhibitor SU5402: Sox3 (G), Sox2 (H) and Chordin (I) are still induced. Note that the concentration of SU5402 used is sufficient to block gastrulation and endogenous expression of these markers. Image published in: de Almeida I et al. (2008) Copyright © 2008. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue sox3.S Sry, Xlsox3, xSox3, Xtsox3 X. laevis Throughout NF stage 19 neuroectoderm neural plate preplacodal ectoderm sox2.L anop3, LOC108718087, mcops3, Sox-2, XLSOX-2, Xsox-2, XSox2 X. laevis Throughout NF stage 20 neuroectoderm neural plate chrd.S chd, chordin, chrd.1, LOC108716939, X-chordin X. laevis Throughout NF stage 20 notochord Image source: Published Larger Image Printer Friendly View

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