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Supplementary Figure S2. δSmad7 acts like Smad6. (A-D) Injection of δSmad7 (together with 10 pg of TEV) and immediate activation by Dexamethasone in one blastomere at the 2-cell stage expands the neural plate, as seen by Sox3 (A, B) and Sox2 (C, D) expression. (E) Effects of decreasing concentrations of δSmad7 mRNA on the expansion of Sox3 expression, in a similar experiment. +DEX, injected embryos activated by Dexamethasone; −DEX, non-activated controls. This experiment shows that at 10 pg δSmad7 the effect is maximal. Image published in: de Almeida I et al. (2008) Copyright © 2008. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue sox3.S Sry, Xlsox3, xSox3, Xtsox3 X. laevis Throughout NF stage 20 neuroectoderm neural plate sox2.L anop3, LOC108718087, mcops3, Sox-2, XLSOX-2, Xsox-2, XSox2 X. laevis Throughout NF stage 20 neuroectoderm neural plate Image source: Published Larger Image Printer Friendly View

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