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Fig. 6. Activin A and RA affect Xlmx1b induction. Animal cap explants taken at stage 8/9 and treated with activin A show induction of Xlmx1b by stage 22 equivalence. This induction is inhibited by the addition of RA in a concentration dependant manner. As xWT-1 is not induced in all the samples in which Xlmx1b is induced, the expression of Xlmx1b may also be from induction of the neural domain. Otx-2 and Hoxb9 were used to identify formation of anterior and posterior neural tissues that could be contributing to Xlmx1b expression. (Expression of Otx-2 in untreated caps is an established phenomenon, Lamb and Harland, 1995). Cardiac actin expression shows the growth factors were effective in inducing mesoderm. Image published in: Haldin CE et al. (2003) Copyright © 2003. Reproduced with permission of the Publisher, University of the Basque Country Press. Larger Image Printer Friendly View

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