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Fig. 8. Model for the Fgf8- and Agrs-based signal exchange between neural and non-neural cells at the anterior neural plate border. Fgf8 produced by the ANB cells induces the expression of Agrs in cells adjacent to the anterior non-neural ectoderm by mediating Ras-dva1 and Otx2. In turn, Agrs secreted by cells in the anterior non-neural ectoderm promote forebrain development through stimulation of both Fgf8 gene expression and Fgf8 protein signaling in the ANB cells. Image published in: Tereshina MB et al. (2014) © 2014. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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