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Figure 4. MyHC immunoreactivity is lost and Z-disc formation recovers in dit. Confocal analysis of wild type (left panels) and dit embryos (right panels) stained with MyHC A4.1025, α-actinin and titin T12 antibodies. (A, C, E) A-bands and Z-discs are well-organized in wild type somites at stage 43. (B) Sarcomeric myosin staining in dit is virtually absent at these stages, but Z-disc-containing sarcomeres are observed (D, F). Phalloidin stained thin filaments are present but disorganized in dit somites. Image published in: Geach TJ and Zimmerman LB (2010) Copyright ©2010 Geach and Zimmerman; licensee BioMed Central Ltd. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Gene Synonyms Species Stage(s) Tissue ttn cmd1g, cmh9, cmpd4, eomfc, hmerf, lgmd2j, LOC108701391, LOC108702272, titin, tmd X. tropicalis Throughout NF stage 43 muscle skeletal muscle myh6 aMHC, ck231, MHC, MHC-alpha, MHCa, MHCalpha, muz, muzak, XCMHC X. tropicalis Throughout NF stage 43 muscle skeletal muscle actn2 X. tropicalis Throughout NF stage 43 muscle skeletal muscle actb beta actin, beta-actin, g-actin X. tropicalis Throughout NF stage 43 muscle skeletal muscle Image source: Published Larger Image Printer Friendly View

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