Xenbase Image ID: 85376

Figure 1. Extracellular protein interactions in Xenopus dorsal-ventral patterning. (A) Chordin inhibits BMPs, which activate expression of Sizzled, an inhibitor of Tolloid proteases that degrades Chordin. (B) The dorsal-ventral network consists of many components under opposite transcriptional control by BMPs [7]. Crescent is a Sizzled homolog expressed in the Spemann Organizer [13]. (C) A simplified pathway in which Chordin and Sizzled regulate each other [8]. The in situ hybridization in the background illustrates that chd and szl mRNAs are expressed at opposite poles of the mid-gastrula [4]. The arrows indicate direct protein�protein interactions in black, transcriptional regulation by BMP signaling in blue, and diffusion (flux) of Chordin/BMP in red. Image published in: De Robertis EM and Colozza G (2013) Copyright © 2013. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue chrd.S chd, chordin, chrd.1, LOC108716939, X-chordin X. laevis Throughout NF stage 11 dorsal dorsal marginal zone involuted dorsal mesoderm upper blastopore lip szl.L frzb3, secreted frizzled, sizzled, xszl X. laevis Throughout NF stage 11 ventral marginal zone Image source: Published Larger Image Printer Friendly View

Return to previous page