Xenbase Image ID: 87031

Figure 1. Dvl is essential for ciliogenesis in multi-ciliated cells. (a) The epidermis of the Xenopus embryo is composed of multi-ciliated cells and mucus-secreting cells. Ciliated cells, labeled by alpha-tubulin immunostaining (red), are evenly spaced between mucus-secreting cells. Polarized beating of cilia generates directional flow across the epithelium16, 26. (b) Normal ciliated cell from a control-injected embryo (injected with a mismatched morpholino). (c) Defective cilia outgrowth in Dvl1–Dvl3 double morphants. (d) Wider field view of control (mismatch morpholino–injected) embryo. (e) Wider field view of Dvl1–Dvl3 double morphant embryo showing many affected cells. Image redisplayed with permission from Macmillan Publishers Ltd. Image published in: Park TJ et al. (2008) Copyright © 2008. Image reproduced with permission of the Publisher, Macmillan Publishers Ltd. Gene Synonyms Species Stage(s) Tissue tuba8.S tubal2 X. laevis Throughout NF stage 29 and 30 epidermis ciliated epidermal cell Image source: Published Larger Image Printer Friendly View

Return to previous page