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DOID:12217 - Lewy body dementia
Disease Ontology Definition:A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities that has_material_basis_in accumulation of alpha-synuclein, SCNA, (protein). The causal mutation might be in SCNA or SCNB or some other gene(s) but the end result is always accumulation of SCNA in Lewy bodies.
Synonyms: Diffuse Lewy body disease (disorder), Senile dementia of the Lewy body type (disorder), Diffuse Lewy body disease, Lewy body disease, Senile dementia of the Lewy body type, Dementia with Lewy bodies
Xenbase Genes
:
sncb,
snca,
gba1
| MONDO:0007488 - Lewy body dementia |
| MIM:127750 - DEMENTIA, LEWY BODY; DLB |
Other Model Organisms: Alliance, MGI, ZFIN, FlyBase, WormBase, RGD
Ontology Viewers: Disease Ontology, EMBL-EBI, OLSVis tree view
Parent(s):
dementia (is_a),
synucleinopathy (is_a)