Figure S6. Combined Loss of T-box TFs Abrogates Neuromesodermal Bipotency, Paraxial Mesoderm Development, and other Mesoderm-Associated Developments, Related to Figure 6Gastrula-staged snapshots of Eomes, VegT and Xbra binding nearby actc1 (A), LOC733709 (C), esr5 (D), delta2 (E), not (F), ventx2.1 (G), gdf3 (H), wnt11 (I), fgf8 (J), aldh1a2 (K) and cyp26a1 (L). RNAPII and poly(A) RNA transcript profiles are taken from Akkers et al. (2009). WMISH on control, Xbra/Xbra3, Xbra/Xbra3/Eomes, Xbra/Xbra3/zVegT and Xbra/Xbra3/Eomes/zVegT KD embryos for target genes (A),(C)-(L) and the muscle-specific differentiation marker myosin heavy chain 1 (myh1) (B) at distinct developmental stages. Early (stage 10.5-11) and late (stage 11.5-12) gastrula, vegetal view; early neurula (stage 13-14), dorsal view; early tailbud (stage 19-20), lateral view (small image, dorsal view); mid-tailbud (stage 25-26), lateral view; embryos from stage 13-20, posterior to the right. Scale bar, 0.5 mm.
Image published in: Gentsch GE et al. (2013)
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