Fig. 2. Posterior Hox and PSM markers are reduced by RARγ-selective agonist and expanded by RARγ-selective inverse agonist. (A-F) WISH from embryos treated post-gastrulation (stage 12.5) with 10 nM 4647, 0.5 µM 5099 or vehicle (0.1% ethanol). Dashed red line represents half the embryo axis. 4647 diminishes and 5099 expands the expression of (A) Hoxd10 (4647, 16/16; 5099, 17/17 embryos), (B) Hoxc10 (4647, 14/14; 5099, 21/21), (C) Hoxc13 (4647, 12/12; 5099, 16/16), (D) Tbx6 (4647, 11/12; 5099, 17/17), (E) Msgn1 (4647, 15/15; 5099, 14/14), and (F) Rarγ2 (4647, 15/15; 5099, 9/9) relative to control vehicle. Embryos shown in lateral or dorsal view at tailbud stage, anterior to left.
Image published in: Janesick A et al. (2014)
Copyright © 2014. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
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