Extended Data Figure 2. Phenotypic characterization of reproductive organs and brain in miR-34/449 TKO mice a. Adult male and female miR-34/449 TKO mice are infertile. Male (left) and female (right) reproductive organs from littermate-controlled DKO and TKO mice were subjected to H&E staining. n=3. Boxes indicate areas depicted in Figure 1e. b. Adult mir-34a-/-; mir-449-/- DKO male mice exhibit no defects in spermatogenesis. c. Adult mir-34a-/-; mir-34b/34c-/- DKO female mice display no defects in reproductive organs. d. The adult mir-34/449 TKO brains do not exhibit hydrocephalus, yet they are smaller in size than wild-type and DKO controls. a/b: the coronal to horizontal ratios. n=3 for b, c and d.
Image published in: Song R et al. (2014)
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