Fig. 7. The effect of the L-type Ca2+ channel antagonist, R(+) BayK, on calcium signalling. (A-B) Luminometry profiles of calcium in embryos, (A) treated with R(+)BayK from stage 8 and (B) untreated (control). Aequorin was injected into the 2 dorsal micromeres at the 8-cell stage so that it was localised in the dorsal ectoderm during gastrulation. In the presence of R(+)BayK no Ca2+ signal was detected, compared to the significant Ca2+ activity (both a single slow rising component and multiple rapid transients) observed in the controls. (C) Comparative morphology of the R(+)BayK-treated embryo and the sibling untreated (control) embryo at stage 25.
Image published in: Leclerc C et al. (2000)
Copyright © 2000. Image reproduced with permission of the Publisher, The Company of Biologists Ltd.
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