Fig S5 – Differential Isoform Dynamics in Clutch A polyA+, related to Fig 3. (A) Explanation and detection of differential isoform dynamics. Left: isoform expression in transcripts/embryo. Center: Joint model of all isoforms assumed to have the same expression on z-normalized scale (see Supplemental Experimental Methods). Right: Models of all isoforms considered separately. If Bayesian Information Criterion (BIC) favors the joint model, the gene has differential abundance, whereas if the BIC favors the individual models a gene has differential dynamics. eef1a1 has differential abundance, nek2 and lima1 have differential dynamics. (B) Differential dynamics of groups of isoforms, BIC graph (left) between all lima1 isoforms. lima2(1) and lima2(2) have differential abundance, and they have differential dynamics with lima2(3) defining two groups of isoforms (right).
Image published in: Owens ND et al. (2016)
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