Fig. 4. Gene Set Enrichment Analysis (GSEA) of dorsal and ventral gene signatures. (A–B) The dorsal gene signature (comprised of 107 genes) positively correlated with Chordin (P<0.001), a Spemann organizer marker, and negatively correlated (or anti-correlated) with BAMBI (P<0.001), a marker of ventral tissues. (C–D) The ventral signature (which contains 70 genes) positively correlated with BAMBI (P<0.001), while it negatively correlated with Chordin (P<0.001). (E) SMC1A, used here as a negative control, did not correlate with the dorsal (P=0.355) nor the ventral (not shown) signature. (F) Pkdcc, a novel dorsal gene described here, significantly correlated with the dorsal gene signature (P<0.001).
Image published in: Ding Y et al. (2017)
Copyright © 2017. Image reproduced with permission of the Publisher, Elsevier B. V.
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