Fig. 7. Model of the proposed mechanism by which Tbx2 inhibits FGF signaling to regulate anterior neural formation. Tbx2 acts as a target gene of BMP signal to suppress the expression of Flrt3. Flrt3 potentiates FGF signaling (dashed arrow) and FGF signals can induce Flrt3 expression, creating a positive feedback loop. On the other hand, FGF signals inhibit BMP signaling by inducing the phosphorylation of Smad1 in its linker region (dashed line). Thus, it appears that the BMP/Tbx2 and FGF/Flrt3 pathways antagonize each other for the correct patterning of anterior neural tissues.
Image published in: Cho GS et al. (2017)
Copyright © 2017. Image reproduced with permission of the Publisher, Elsevier B. V.
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