Fig. 2. Immature eggs produce stereotyped hyperventral and anterior defects. All panels show normal (top) and defective (lower) sibling embryos. Panel A shows hyperventralization phenotype at stage 27. Panels B show stereotyped midline and anterior defects. A combined in situ hybridization for shh (midline), olig2 (intermediate staining), and slug (neural plate border) reveals defective dorsal midline development of stage 15 sibling embryos (Panel B). Panels C and D show anterior defects at stage 24 and 37/38 embryos, respectively. Panel E shows stage 37/38 embryos stained for pax2 (neural, otic vesicle, kidney) and globin (ventral blood islands). Panels F and G show stage 41 embryos. In all panels, anterior is to the left. Dorsal views are shown in Panels B and G, all other panels are lateral views.
Image published in: Grammer TC et al. (2005)
Copyright © 2005. Image reproduced with permission of the Publisher, Elsevier B. V.
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