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Figure 4. The Nine Members of the Gastrula Defect Phenotypic Class Note that the blastopore in control embryos is closing normally, but is either absent or severely delayed in embryos in which the functions of the indicated genes are inhibited. All embryos shown are at gastrula stage 10.5 to 11.5. In this figure and in Figures 5�13, the number in the top left hand side of each panel represents the synphenotype group to which the embryos belong, and the name of the gene in question is shown bottom left. doi:10.1371/journal.pgen.0020193.g004

Image published in: Rana AA et al. (2006)

Copyright © 2006. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license

Experiment + Assay Source Phenotypes and Disease
Xtr Wt + cbx1 MO + NF10.5-11.5 (morphology) fig.4
Anatomical Phenotype
abnormal gastrulation
absent blastopore
Xtr Wt + ccdc174 MO + NF10.5-11.5 (morphology) fig.4
Anatomical Phenotype
abnormal blastopore morphology
abnormal central endoderm morphology
abnormal gastrulation
Xtr Wt + cdh3 MO + NF10.5-11.5 (morphology) fig.4
Anatomical Phenotype
abnormal blastopore morphology
abnormal gastrulation
Xtr Wt + dmd.1 MO + NF10.5-11.5 (morphology) fig.4
Anatomical Phenotype
abnormal blastopore morphology
abnormal gastrulation
Xtr Wt + dync1li1 MO + NF10.5-11.5 (morphology) fig.4
Anatomical Phenotype
abnormal blastopore morphology
abnormal gastrulation
Xtr Wt + hmg20b MO + NF10.5-11.5 (morphology) fig.4
Anatomical Phenotype
abnormal blastopore morphology
abnormal gastrulation
Xtr Wt + suv39h1 MO + NF10.5-11.5 (morphology) fig.4
Anatomical Phenotype
abnormal blastopore morphology
abnormal gastrulation
Xtr Wt + wnt5b MO + NF10.5-11.5 (morphology) fig.4
Anatomical Phenotype
abnormal blastopore morphology
abnormal gastrulation
Xtr Wt + znf207 MO + NF10.5-11.5 (morphology) fig.4
Anatomical Phenotype
abnormal blastopore morphology
abnormal gastrulation

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