Larger Image Figure 6. The Second 32 Members of the Shortened Axis Phenotypic Class This class can be subdivided into six synphenotype groups, as indicated in Figure 3 and Table 4. The figure shows examples of the fourth synphenotype group (short axis surviving to tadpole) at tadpole stages 35�41. doi:10.1371/journal.pgen.0020193.g006 Image published in: Rana AA et al. (2006) Copyright © 2006. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Experiment + Assay Source Phenotypes and Disease Xtr Wt + ahnak MO + NF28 (morphology) fig.6, Table 4 Anatomical Phenotype abnormal axis elongation abnormal tail bud morphology decreased length of anterior-posterior axis decreased size of the tail bud Xtr Wt + ahnak MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal axis elongation abnormal dorsal fin morphology abnormal head morphology abnormal tail bud morphology decreased length of anterior-posterior axis decreased size of the tail bud Xtr Wt + calhm2 MO + NF10-10.5 (morphology) fig.6, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + calhm2 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal anterior-posterior axis, curved dorsal abnormal head morphology decreased length of anterior-posterior axis Xtr Wt + calhm2 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis decreased size of the whole organism Xtr Wt + chn1 MO + NF28 (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail bud morphology decreased length of anterior-posterior axis Xtr Wt + chn1 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis decreased size of the head Xtr Wt + dlg1 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal swimming behavior abnormal tail morphology decreased length of anterior-posterior axis decreased size of the tail Xtr Wt + dmd.2 MO + NF10.5-11.5 (morphology) fig.6, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + dmd.2 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail bud morphology absent head decreased length of anterior-posterior axis Xtr Wt + dmd.2 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal somite morphology abnormal swimming behavior absent head absent swimming behavior decreased length of anterior-posterior axis Xtr Wt + dynlt1 MO + gastrula stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + dynlt1 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail bud morphology decreased length of anterior-posterior axis Xtr Wt + dynlt1 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis decreased size of the head decreased size of the tail Xtr Wt + fam214a MO + NF10.5-11.5 (morphology) fig.6, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + fam214a MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + fam214a MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail morphology absent eye decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + fzd6 MO + NF10.5-11.5 (morphology) fig.6, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + fzd6 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal neural tube closure abnormal tail bud morphology decreased length of anterior-posterior axis Xtr Wt + fzd6 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail bud morphology decreased length of anterior-posterior axis Xtr Wt + fzd7 MO + NF10.5-11.5 (morphology) fig.6, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + fzd7 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail bud morphology decreased length of anterior-posterior axis Xtr Wt + fzd7 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal whole organism morphology decreased length of anterior-posterior axis Xtr Wt + hap1 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype decreased length of anterior-posterior axis Xtr Wt + hap1 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail morphology abnormally ruffled dorsal fin Xtr Wt + ing2 MO + NF10.5-11.5 (morphology) fig.6, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + ing2 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail bud morphology decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + ing2 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail bud morphology abnormally ruffled dorsal fin decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + ing5 MO + NF10.5-11.5 (morphology) fig.6, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + ing5 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail bud morphology decreased length of anterior-posterior axis obsolete abnormally edematous dorsal fin Xtr Wt + itgb1 MO + NF10.5-11.5 (morphology) fig.6, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + itgb1 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail bud morphology decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + itgb1 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail bud morphology decreased length of anterior-posterior axis Xtr Wt + lhx1 MO + NF10-10.5 (morphology) fig.6, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + lhx1 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail bud morphology abnormal tail morphology decreased length of anterior-posterior axis Xtr Wt + ncaph2 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal development of embryo Xtr Wt + ncaph2 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis edematous ventral trunk Xtr Wt + nradd MO + NF10.5-11.5 (morphology) fig.6, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + nradd MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail bud morphology decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + nradd MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal tail bud morphology decreased length of anterior-posterior axis Xtr Wt + padi2 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal development of embryo abnormal head morphology abnormal tail bud morphology decreased length of anterior-posterior axis Xtr Wt + padi2 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal somitogenesis abnormal tail bud morphology decreased length of anterior-posterior axis Xtr Wt + pinx1 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype decreased length of anterior-posterior axis Xtr Wt + pinx1 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis decreased size of the head Xtr Wt + prkci MO + NF10-10.5 (morphology) fig.6, Table 4 Anatomical Phenotype abnormal gastrulation absent blastopore Xtr Wt + prkci MO + tailbud stage-tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis Xtr Wt + rbl2 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal whole organism morphology decreased length of anterior-posterior axis Xtr Wt + rbl2 MO + tailbud stage-tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype arrested axis elongation Xtr Wt + rbl2 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal bending of tail abnormal head morphology absent eye decreased length of anterior-posterior axis decreased size of the tail Xtr Wt + rtfdc1 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal development of embryo decreased length of anterior-posterior axis Xtr Wt + smad3 MO + NF10-10.5 (morphology) fig.6, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + smad3 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype absent tail bud decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + smad3 MO + tailbud stage-tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype absent head Xtr Wt + smad3 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal bending of tail abnormal development of embryo decreased length of anterior-posterior axis Xtr Wt + suv39h2 MO + NF10-10.5 (morphology) fig.6, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + suv39h2 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal development of embryo decreased length of anterior-posterior axis Xtr Wt + suv39h2 MO + tailbud stage-tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype absent head Xtr Wt + suv39h2 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal bending of tail Xtr Wt + tbx2 MO + NF10-10.5 (morphology) fig.6, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + tbx2 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal tail bud morphology absent tail bud decreased length of anterior-posterior axis Xtr Wt + tbx2 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal whole organism morphology decreased length of anterior-posterior axis Xtr Wt + tbx2 MO + tailbud stage-tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology absent head Xtr Wt + tbx2 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal bending of tail absent head decreased length of anterior-posterior axis Xtr Wt + tbx2 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal tail bud morphology decreased length of anterior-posterior axis Xtr Wt + tbx2 MO + tadpole stage-tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal trunk morphology Xtr Wt + tbx6 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal development of tail decreased length of anterior-posterior axis decreased size of the tail bud wholly ventralized embryo Xtr Wt + tbx6 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype edematous ventral trunk Xtr Wt + tp53 MO + NF10-10.5 (morphology) fig.6, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + tp53 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail bud morphology decreased length of anterior-posterior axis Xtr Wt + tp53 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal axis elongation abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis Xtr Wt + trmt61a + NF10-10.5 (morphology) fig.6, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + trmt61a + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail morphology absent swimming behavior arrested axis elongation decreased length of anterior-posterior axis Xtr Wt + tsg101 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal development of embryo abnormal head morphology abnormal tail bud morphology decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + tsg101 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis decreased size of the eye Xtr Wt + ubn2 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal development of embryo Xtr Wt + ubn2 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis decreased size of the trunk Xtr Wt + znf326 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal development of embryo abnormal head morphology abnormal tail bud morphology decreased length of anterior-posterior axis Xtr Wt + znf326 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal bending of tail abnormal development of embryo abnormal tail morphology decreased length of anterior-posterior axis Xtr Wt + znf674 MO + tailbud stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal head morphology abnormal tail bud morphology decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + znf674 MO + tadpole stage (morphology) fig.6, Table 4 Anatomical Phenotype abnormal bending of tail abnormal head morphology abnormal heart morphology abnormally ruffled dorsal fin decreased length of anterior-posterior axis decreased size of the head wholly ventralized embryo Permanent Image Page Printer Friendly View XB-IMG-82961