Figure 3. The utility of Xenopus in drug discovery and development. The two broad strategies of drug discovery and development are shown. The target-based strategy requires a functional understanding of the disease pathway to determine target genes or proteins for drug discovery and development. The activity-based strategy selects for drug candidates on the basis of biological activities implicated with a therapeutic benefit. The Xenopus embryos and tadpoles can serve as cheap and efficient bioassay tools at several stages of the drug-discovery process regardless of the strategy chosen. SAR, structure-activity-relationship.Download figure to PowerPoint
Image published in: Wheeler GN and Brändli AW (2009)
Copyright © 2009. Image reproduced with permission of the Publisher, John Wiley & Sons.
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