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FIGURE S5. Genes involved in cancer show different patterns of expression. A, spatial expression of genes that promote or are upregulated during cancer development/progression. B, spatial expression of genes that can play dual roles (promote or are upregulated in some cancer types while repress or are downregulated in some other types) during the development/progression of different cancer types. Each embryo is oriented with the anterior to the left. Dorsal view is shown for neurula embryos, and lateral view is shown for tailbud, with dorsal side to the top of each panel. Typical expression domains are labeled but the same expression domain in different panels may not be labeled repeatedly. A, anterior; ad, adenohypophysial placode; anp, anterior neural plate; anpb, anterior neural plate border; ba, branchial arch; cg, cement gland; cgp, cement gland primordium; cnh, chordoneural hinge; cnp, chordal neural plate; d, dorsal view; ep, epidermis; ev, ear vesicle; ey, eye; fb, forebrain; hb, hindbrain; l, lateral view; mb, midbrain; ng, neural groove; np, neural plate; npb, neural plate border; P, posterior; pd, pronephric duct; pm, paraxial mesoderm; ps, posterior somite; sc, spinal cord; sm, somite; tg, trigeminal nerve.

Image published in: Zhang Z et al. (2017)

Copyright © 2017. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.

GeneSynonymsSpeciesStage(s)Tissue
ret.Scret, c-ret, X-ret, xretX.laevisSometime during NF stage 15 to NF stage 20 
ret.Scret, c-ret, X-ret, xretX.laevisSometime during NF stage 26 to NF stage 32trigeminal ganglion
intermediate mesoderm
pharyngeal region
smad4.LXSmad4alpha, Xsmad4, jip, dpc4, madh4, XSmad4a, smad4a, smad4alpha, smad4.1X.laevisSometime during NF stage 15 to NF stage 20neuroectoderm
neural plate
ectoderm
smad4.LXSmad4alpha, Xsmad4, jip, dpc4, madh4, XSmad4a, smad4a, smad4alpha, smad4.1X.laevisSometime during NF stage 26 to NF stage 32brain
forebrain
midbrain
hindbrain
head
eye
pharyngeal region
tail bud
otic vesicle
central nervous system
presomitic mesoderm
axl.Lufo, jtk11X.laevisSometime during NF stage 15 to NF stage 20epidermis
axl.Lufo, jtk11X.laevisSometime during NF stage 26 to NF stage 32proctodeum
head
spinal cord
hgf.LX.laevisSometime during NF stage 15 to NF stage 20neural plate border
hgf.LX.laevisSometime during NF stage 26 to NF stage 32head
neurogenic placode
jak2.LX.laevisSometime during NF stage 15 to NF stage 20neuroectoderm
neural plate
jak2.LX.laevisSometime during NF stage 26 to NF stage 32notochord
nras.Ln-ras, nras1X.laevisSometime during NF stage 15 to NF stage 20ectoderm
nras.Ln-ras, nras1X.laevisSometime during NF stage 26 to NF stage 32notochord
pik3ca.Lpi3k, PI3K-alpha, PI3-kinase, pi3-kX.laevisSometime during NF stage 15 to NF stage 20neuroectoderm
neural plate
pik3ca.Lpi3k, PI3K-alpha, PI3-kinase, pi3-kX.laevisSometime during NF stage 26 to NF stage 32brain
forebrain
midbrain
central nervous system
somite
head
eye
pharyngeal region
pim1.Lpim-1, pim, pim1a, pim3X.laevisSometime during NF stage 15 to NF stage 20neural plate border
neuroectoderm
paraxial mesoderm
pim1.Lpim-1, pim, pim1a, pim3X.laevisSometime during NF stage 26 to NF stage 32brain
forebrain
midbrain
hindbrain
central nervous system
spinal cord
eye
branchial arch
pharyngeal region
intermediate mesoderm
slc16a1.Smct1X.laevisSometime during NF stage 15 to NF stage 20neuroectoderm
neural plate
ectoderm
slc16a1.Smct1X.laevisSometime during NF stage 26 to NF stage 32head
brain
eye
pharyngeal region
presomitic mesoderm
tert.Lxtert, est2, tcs1, tp2, trt, telomeraseX.laevisSometime during NF stage 15 to NF stage 20 
tert.Lxtert, est2, tcs1, tp2, trt, telomeraseX.laevisSometime during NF stage 26 to NF stage 32 
vav2.SX.laevisSometime during NF stage 15 to NF stage 20neuroectoderm
neural plate
vav2.SX.laevisSometime during NF stage 26 to NF stage 32hindbrain
head
brain
zeb1.Ltcf8, bzp, zeb, areb6, nil2a, zfhep, nil-2a, zfhx1, deltaef1, fecd6X.laevisSometime during NF stage 15 to NF stage 20neuroectoderm
neural plate
chordal neural plate
zeb1.Ltcf8, bzp, zeb, areb6, nil2a, zfhep, nil-2a, zfhx1, deltaef1, fecd6X.laevisSometime during NF stage 26 to NF stage 32intersomitic region
presomitic mesoderm
tail tip
head
eye
pharyngeal region
brain
forebrain
midbrain
hindbrain
midbrain-hindbrain boundary
branchial arch
prkaa1.Sampk, ampka1X.laevisSometime during NF stage 15 to NF stage 20neuroectoderm
neural plate
prkaa1.Sampk, ampka1X.laevisSometime during NF stage 26 to NF stage 32chordoneural hinge
somite
pronephric duct
brain
forebrain
midbrain
hindbrain
otic vesicle
head
eye
pharyngeal region
hras.LH-Ras, K-Ras, hras1, rash1X.laevisSometime during NF stage 15 to NF stage 20ectoderm
hras.LH-Ras, K-Ras, hras1, rash1X.laevisSometime during NF stage 26 to NF stage 32head
periotic region
mcam.LX.laevisSometime during NF stage 15 to NF stage 20 
mcam.LX.laevisSometime during NF stage 26 to NF stage 32trigeminal ganglion
midbrain
intersomitic region
presomitic mesoderm
pkm.Lcthbp, pyruvate kinase, pk3, pk, pkX.laevisSometime during NF stage 15 to NF stage 20neuroectoderm
neural plate
pkm.Lcthbp, pyruvate kinase, pk3, pk, pkX.laevisSometime during NF stage 26 to NF stage 32midbrain
eye
somite
otic vesicle
ptgs2.Scox2, cox-2, phs-2, pgg/hs, pghs-2, gripghsX.laevisSometime during NF stage 15 to NF stage 20neural groove
epidermis
ptgs2.Scox2, cox-2, phs-2, pgg/hs, pghs-2, gripghsX.laevisSometime during NF stage 26 to NF stage 32dorsal fin
ventral tail fin
smad1.SXsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisSometime during NF stage 15 to NF stage 20neuroectoderm
neural plate
ectoderm
smad1.SXsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisSometime during NF stage 26 to NF stage 32brain
forebrain
midbrain
hindbrain
central nervous system
spinal cord
eye
intermediate mesoderm
head
pharyngeal region
tail bud
branchial arch
hyoid crest
cranial neural crest
ahr.LbHLHe76X.laevisSometime during NF stage 15 to NF stage 20 
ahr.LbHLHe76X.laevisSometime during NF stage 26 to NF stage 32eye
otic vesicle
pharyngeal region

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