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FIGURE 1 Expression patterns of p2ry4 during early development. WISH of p2ry4 from gastrula to tailbud stage. Stages 10.5 and 11 (a and c, dorsal views; b and d, sagittal hemisections). p2ry4 was expressed in the prospective neuroectoderm and the involuting dorsal and ventral mesoderm at gastrula stage. At stage 10.5, p2ry4 was prominently expressed in the head organizer region (b). Stages 13, 17, 19, and 21 (e, f, h, j, anterior views; k, dorsal view; g, sagittal hemisection; i, transverse section). Stage 28 (l, lateral view; m, transverse section; m’, high-magnification image of m). The extirpated brain of tadpole (n, lateral side; o, dorsal side). nc, neural crest; pl, placode cell; anp, anterior neural plate; mhb, midbrain-hindbrain boundary; nt, neural tube; not, notochord; som, somite; cg, cement gland; tel, telencephalon; di, diencephalon; mes, mesencephalon; met, metencephalon. Dotted straight line indicates section plane. Black arrowheads indicate blastopore

Image published in: Harata A et al. (2019)

Copyright © 2019. Image reproduced with permission of the Publisher, John Wiley & Sons.

p2ry4.LXlP2YX.laevisThroughout NF stage 10.5dorsal marginal zone
upper blastopore lip
involuting marginal zone
p2ry4.LXlP2YX.laevisThroughout NF stage 11involuting marginal zone
dorsal marginal zone
ventral marginal zone
upper blastopore lip
p2ry4.LXlP2YX.laevisThroughout NF stage 13anterior placodal area
neural crest
neural plate
neural plate border
p2ry4.LXlP2YX.laevisThroughout NF stage 17anterior neural fold
neural plate
p2ry4.LXlP2YX.laevisThroughout NF stage 19presumptive midbrain-hindbrain boundary
neural groove
neural plate
p2ry4.LXlP2YX.laevisThroughout NF stage 21presumptive midbrain-hindbrain boundary
neural plate
neural tube
p2ry4.LXlP2YX.laevisThroughout NF stage 28midbrain
midbrain-hindbrain boundary
pharyngeal region
neural tube
otic vesicle
p2ry4.LXlP2YX.laevisThroughout NF stage 45diencephalon
midbrain-hindbrain boundary

Image source: Published

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