Fig. 1. Cardia bifida is evident in GATA4, 5 and 6 morphants, but cardiac gene expression is only affected in GATA6 depleted Xenopus embryos. (A) Cardiac tissue stained for MLC fails to migrate to the midline in embryos injected singly with GATA4, 5 or 6 morpholinos. (B, C) Expression levels of MLC, Nkx2.5, Tbx5 and CA remain unchanged in GATA4 and 5 morphants compared with control uninjected embryos at stage 28. (D) Expression levels of MLC, Nkx2.5, Tbx5 and CA are substantially decreased in GATA6 morphants at stage 28.
Image published in: Peterkin T et al. (2007)
© 2007 Elsevier Inc. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives license
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| tbx5.S | tbx-5, tbx5-a, tbx5-b, xtbx-5, xtbx5 | X. laevis | Throughout NF stage 28 | cardiac mesoderm heart primordium dorsal retina lateral plate mesoderm |
| nkx2-5.L | AR2, csx, Nkx-2.5, nkx-2.5, nkx2-5-a, nkx2-5-b, nkx2.5, tinman, XNkx-2.5, XNkx2-5 | X. laevis | Throughout NF stage 28 | cardiac mesoderm heart primordium |
| myo1c.S | mmib, myo1c-a, myo1c-b, myr2, nm1, nuclear myosin 1 | X. laevis | Throughout NF stage 28 | cardiac mesoderm heart primordium |
| actc1.L | actc, actna1, cardiac actin, cardiac alpha actin, muscle actin | X. laevis | Throughout NF stage 28 | cardiac mesoderm heart primordium somite paraxial mesoderm |
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