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XB-PHENO-16448

Xla. Wt + pax6 CRISPR, Viet J et al. (2020)

Experiment + Assay: Xla. Wt + pax6 CRISPR + NF41-NF42 (stained tissue microscopy)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR pax6 pax6.S
pax6.L
 NF stage 1 zygote
Conditions:
Assay Type Assay Stages Antibody
stained tissue microscopy NF stage 41 to NF stage 42  
Anatomical Phenotypes: absent lens , absent retinal ganglion cell layer , absent retinal outer nuclear layer , decreased size of the photoreceptor layer , decreased size of the retinal inner nuclear layer , decreased size of the retinal pigmented epithelium
Source: Fig. 2. E, row3
Article: XB-ART-56586, PubMed