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XB-PHENO-22972

Xla Wt + Mmu.fgfr1del-Mmu.fkbp1adel + wnt2 MO + B/B Homodimerizer, Rankin SA et al. (2015)

Experiment + Assay: Xla Wt + Mmu.fgfr1del-Mmu.fkbp1adel + wnt2 MO + B/B Homodimerizer + NF42 (immunohistochemistry)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection wnt2 MO1 wnt2.L
wnt2.S
 NF stage 3 (4-cell) blastomere
mRNA injection Tg(Mmu.fgfr1del-Mmu.fkbp1adel) fgfr1.L
fgfr1.S
 NF stage 4 (8-cell) blastomere
chemical B/B Homodimerizer
NF stage 25 whole organism
Conditions:
Assay Type Assay Stages Antibody
immunohistochemistry NF stage 42  
Expression Phenotypes (2):
decreased amount nkx2-1.L expression in foregut
mislocalised sox2.S expression in foregut endoderm
Source: fig.10.n
Article: XB-ART-49397, PubMed