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XB-PHENO-23533

Xla Wt + adprhl1 CRISPR, Smith SJ et al. (2020)

Experiment + Assay: Xla Wt + adprhl1 CRISPR + NF40-42 (immunohistochemistry)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR adprhl1 gRNA4 adprhl1 (Xla)
 NF stage 1 zygote
Conditions:
Assay Type Assay Stages Antibody
immunohistochemistry NF stage 40 to NF stage 42 Myh6 Ab1
Anatomical Phenotypes: abnormal actin cytoskeleton morphology , abnormal cardiac myocyte morphology , abnormal development of cardiac ventricle , abnormal myofibril morphology , abnormal sarcomere morphology , abnormally localised outflow tract , decreased size of the cardiac ventricle
Source: Fig.7.A-D,I-L
Article: XB-ART-57216, PubMed