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XB-PHENO-24159

Xtr.tp53em_del1/em_del2_Vlemx + rb1 CRISPR + rbl1 CRISPR, Naert T et al. (2020)

Experiment + Assay: Xtr.tp53em_del1/em_del2_Vlemx + rb1 CRISPR + rbl1 CRISPR + adult (histology)
Background: Xtr.tp53em_del1/em_del2_Vlemx
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR rb1 rb1
 NF stage 4 (8-cell) dorsal animal hemisphere blastomere
CRISPR rbl1 rbl1
 NF stage 4 (8-cell) dorsal animal hemisphere blastomere
Conditions:
Assay Type Assay Stages Antibody
histology adult frog stage to adult frog stage  
Anatomical Phenotypes: abnormal brain morphology
Human Disease Associations: medulloblastoma, pineoblastoma, glioblastoma, choroid plexus cancer
Source: Fig. 3 E
Article: XB-ART-56659, PubMed