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XB-PHENO-24160

Xtr Wt + rb1 CRISPR + rbl1 CRISPR + tp53 CRISPR, Naert T et al. (2020)

Experiment + Assay: Xtr Wt + rb1 CRISPR + rbl1 CRISPR + tp53 CRISPR + adult (whole-mount microscopy)
Background: Xtr.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR rb1 rb1
 NF stage 4 (8-cell) dorsal vegetal hemisphere blastomere
CRISPR tp53 tp53
 NF stage 4 (8-cell) dorsal vegetal hemisphere blastomere
CRISPR rbl1 rbl1
 NF stage 4 (8-cell) dorsal vegetal hemisphere blastomere
Conditions:
Assay Type Assay Stages Antibody
whole-mount microscopy adult frog stage to adult frog stage  
Anatomical Phenotypes: abnormal pancreas morphology
Human Disease Associations: pancreatic cancer
Source: Fig. 2 B
Article: XB-ART-56659, PubMed