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XB-PHENO-24247

Xla Wt + ptpn11N308D, Langdon Y et al. (2012)

Experiment + Assay: Xla Wt + ptpn11N308D + NF33/34-37/38 (transmission electron microscopy)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
DNA injection Tg(ptpn11N308D) ptpn11 (Xla)
 NF stage 1 embryo
Conditions:
Assay Type Assay Stages Antibody
transmission electron microscopy NF stage 33 and 34 to NF stage 37 and 38  
Anatomical Phenotypes: abnormal sarcomere
Human Disease Associations: Noonan syndrome
Source: Fig. 5 KM
Article: XB-ART-44762, PubMed