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Profile Publications(91)

Publications By Jin-Kwan Han

Results 1 - 50 of 91 results

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Rational design and biological evaluation of gemfibrozil modified Xenopus GLP-1 derivatives as long-acting hypoglycemic agents., Han J, Fu J, Yang Q, Zhou F, Chen X, Li C, Yin J., Eur J Med Chem. July 15, 2020; 198 112389.

The chronic administration of two novel long-acting Xenopus glucagon-like peptide-1 analogs xGLP159 and xGLP296 potently improved systemic metabolism and glycemic control in rodent models., Han J, Meng T, Chen X, Han Y, Fu J, Zhou F, Fei Y, Li C., FASEB J. January 1, 2019; 33 (6): 7113-7125.

Lipidation and conformational constraining for prolonging the effects of peptides: Xenopus glucagon-like peptide 1 analogues with potent and long-acting hypoglycemic activity., Han J, Huang Y, Chen X, Zhou F, Fei Y, Fu J., Eur J Pharm Sci. October 15, 2018; 123 111-123.

Rational design of dimeric lipidated Xenopus glucagon-like peptide 1 analogues as long-acting antihyperglycaemic agents., Han J, Huang Y, Chen X, Zhou F, Fei Y, Fu J., Eur J Med Chem. September 5, 2018; 157 177-187.

Xenopus-derived glucagon-like peptide-1 and polyethylene-glycosylated glucagon-like peptide-1 receptor agonists: long-acting hypoglycaemic and insulinotropic activities with potential therapeutic utilities., Han J, Fei Y, Zhou F, Chen X, Zhang Y, Liu L, Fu J., Br J Pharmacol. January 1, 2018; 175 (3): 544-557.

Head formation requires Dishevelled degradation that is mediated by March2 in concert with Dapper1., Lee H, Cheong SM, Han W, Koo Y, Jo SB, Cho GS, Yang JS, Kim S, Han JK., Development. January 1, 2018; 145 (7):               

Lithocholic Acid-Based Peptide Delivery System for an Enhanced Pharmacological and Pharmacokinetic Profile of Xenopus GLP-1 Analogs., Han J, Chen X, Zhao L, Fu J, Sun L, Zhang Y, Zhou F, Fei Y., Mol Pharm. January 1, 2018; 15 (7): 2840-2856.

Synthesis and pharmaceutical characterization of site specific mycophenolic acid-modified Xenopus glucagon-like peptide-1 analogs., Han J, Fu J, Sun L, Han Y, Mao Q, Liao F, Zheng X, Zhu K., Medchemcomm. January 1, 2018; 9 (1): 67-80.

A gene regulatory network anchored by LIM homeobox 1 for embryonic head development., Sibbritt T, Ip CK, Khoo PL, Wilkie E, Jones V, Sun JQJ, Shen JX, Peng G, Han JJ, Jing N, Osteil P, Ramialison M, Tam PPL, Fossat N., Genesis. January 1, 2018; 56 (9): e23246.

Design, synthesis and biological evaluation of PEGylated Xenopus glucagon-like peptide-1 derivatives as long-acting hypoglycemic agents., Han J, Wang Y, Meng Q, Li G, Huang F, Wu S, Fei Y, Zhou F, Fu J., Eur J Med Chem. May 26, 2017; 132 81-89.

Tbx2 regulates anterior neural specification by repressing FGF signaling pathway., Cho GS, Park DS, Choi SC, Han JK., Dev Biol. January 15, 2017; 421 (2): 183-193.              

Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling., Han W, Lee H, Han JK., Sci Rep. January 1, 2017; 7 42590.                        

Xenopus GLP-1-inspired discovery of novel GLP-1 receptor agonists as long-acting hypoglycemic and insulinotropic agents with significant therapeutic potential., Han J, Chen X, Wang Y, Fei Y, Zhou F, Zhang Y, Liu L, Si P, Fu J., Biochem Pharmacol. January 1, 2017; 142 155-167.

Micellar Nanomedicine of Novel Fatty Acid Modified Xenopus Glucagon-like Peptide-1: Improved Physicochemical Characteristics and Therapeutic Utilities for Type 2 Diabetes., Han J, Fei Y, Zhou F, Chen X, Zheng W, Fu J., Mol Pharm. January 1, 2017; 14 (11): 3954-3967.

Peroxiredoxin1, a novel regulator of pronephros development, influences retinoic acid and Wnt signaling by controlling ROS levels., Chae S, Lee HK, Kim YK, Jung Sim H, Ji Y, Kim C, Ismail T, Park JW, Kwon OS, Kang BS, Lee DS, Bae JS, Kim SH, Min KJ, Kyu Kwon T, Park MJ, Han JK, Kwon T, Park TJ, Lee HS., Sci Rep. January 1, 2017; 7 (1): 8874.                    

PLD1 regulates Xenopus convergent extension movements by mediating Frizzled7 endocytosis for Wnt/PCP signal activation., Lee H, Lee SJ, Kim GH, Yeo I, Han JK., Dev Biol. March 1, 2016; 411 (1): 38-49.                          

WNK3 Kinase Enhances the Sodium Chloride Cotransporter Expression via an ERK 1/2 Signaling Pathway., Wang D, Zhang Y, Han J, Pan S, Xu N, Feng X, Zhuang Z, Caroti C, Zhuang J, Hoover RS, Gu D, Zeng Q, Cai H., Nephron. January 1, 2016; 133 (4): 287-95.

Gabapentin inhibits the activity of the rat excitatory glutamate transporter 3 expressed in Xenopus oocytes., Gil YS, Kim JH, Kim CH, Han JI, Zuo Z, Baik HJ., Eur J Pharmacol. September 5, 2015; 762 112-7.

Cellular analysis of cleavage-stage chick embryos reveals hidden conservation in vertebrate early development., Nagai H, Sezaki M, Kakiguchi K, Nakaya Y, Lee HC, Ladher R, Sasanami T, Han JY, Yonemura S, Sheng G., Development. April 1, 2015; 142 (7): 1279-86.      

Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling., Sheng R, Kim H, Lee H, Xin Y, Chen Y, Tian W, Cui Y, Choi JC, Doh J, Han JK, Cho W., Nat Commun. July 15, 2014; 5 4393.              

Role of Sp5 as an essential early regulator of neural crest specification in xenopus., Park DS, Seo JH, Hong M, Bang W, Han JK, Choi SC., Dev Dyn. December 1, 2013; 242 (12): 1382-94.                

β-Arrestin 1 mediates non-canonical Wnt pathway to regulate convergent extension movements., Kim GH, Park EC, Lee H, Na HJ, Choi SC, Han JK., Biochem Biophys Res Commun. May 31, 2013; 435 (2): 182-7.                  

BMP signal attenuates FGF pathway in anteroposterior neural patterning., Cho GS, Choi SC, Han JK., Biochem Biophys Res Commun. May 10, 2013; 434 (3): 509-15.        

Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning., Kim WT, Kim H, Katanaev VL, Joon Lee S, Ishitani T, Cha B, Han JK, Jho EH., EMBO J. August 15, 2012; 31 (16): 3384-97.

Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein., Gu SQ, Bakthavachalu B, Han J, Patil DP, Otsuka Y, Guda C, Schoenberg DR., RNA. June 1, 2012; 18 (6): 1186-96.

Analysis of the expression of microtubule plus-end tracking proteins (+TIPs) during Xenopus laevis embryogenesis., Park EC, Lee H, Hong Y, Kim MJ, Lee ZW, Kim SI, Kim S, Kim GH, Han JK., Gene Expr Patterns. May 1, 2012; 12 (5-6): 204-12.                                                              

Effects of clonidine on the activity of the rat glutamate transporter EAAT3 expressed in Xenopus oocytes., Woo JH, Han JI, Baik HJ, Lee H., Korean J Anesthesiol. March 1, 2012; 62 (3): 266-71.    

Wnt/planar cell polarity signaling in the regulation of convergent extension movements during Xenopus gastrulation., Kim GH, Park EC, Han JK., Methods Mol Biol. January 1, 2012; 839 79-89.

Rab3d is required for Xenopus anterior neurulation by regulating Noggin secretion., Kim H, Han JK., Dev Dyn. June 1, 2011; 240 (6): 1430-9.              

Isolation and Expression Profile of the Ca-Activated Chloride Channel-like Membrane Protein 6 Gene in Xenopus laevis., Lee RM, Ryu RH, Jeong SW, Oh SJ, Huang H, Han JS, Lee CH, Lee CJ, Jan LY, Jeong SM., Lab Anim Res. June 1, 2011; 27 (2): 109-16.        

The involvement of Eph-Ephrin signaling in tissue separation and convergence during Xenopus gastrulation movements., Park EC, Cho GS, Kim GH, Choi SC, Han JK., Dev Biol. February 15, 2011; 350 (2): 441-50.                          

Role of Tbx2 in defining the territory of the pronephric nephron., Cho GS, Choi SC, Park EC, Han JK., Development. February 1, 2011; 138 (3): 465-74.                        

Top-down analysis of recombinant histone H3 and its methylated analogs by ESI/FT-ICR mass spectrometry., Han J, Borchers CH., Proteomics. October 1, 2010; 10 (20): 3621-30.

Molecular coevolution of kisspeptins and their receptors from fish to mammals., Um HN, Han JM, Hwang JI, Hong SI, Vaudry H, Seong JY., Ann N Y Acad Sci. July 1, 2010; 1200 67-74.

Molecular cloning and characterization of the germ cell-related nuclear orphan receptor in chickens., Lee SI, Kim JK, Park HJ, Jang HJ, Lee HC, Min T, Song G, Han JY., Mol Reprod Dev. March 1, 2010; 77 (3): 273-84.

XPteg (Xenopus proximal tubules-expressed gene) is essential for pronephric mesoderm specification and tubulogenesis., Lee SJ, Kim S, Choi SC, Han JK., Mech Dev. January 1, 2010; 127 (1-2): 49-61.                  

Negative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of Dishevelled., Jung H, Kim HJ, Lee SK, Kim R, Kopachik W, Han JK, Jho EH., Exp Mol Med. October 31, 2009; 41 (10): 695-706.

Regulation of acetylcholine receptor clustering by ADF/cofilin-directed vesicular trafficking., Lee CW, Han J, Bamburg JR, Han L, Lynn R, Zheng JQ., Nat Neurosci. July 1, 2009; 12 (7): 848-56.              

Identification of a novel negative regulator of activin/nodal signaling in mesendodermal formation of Xenopus embryos., Cheong SM, Kim H, Han JK., J Biol Chem. June 19, 2009; 284 (25): 17052-60.                        

Xenopus Wntless and the retromer complex cooperate to regulate XWnt4 secretion., Kim H, Cheong SM, Ryu J, Jung HJ, Jho EH, Han JK., Mol Cell Biol. April 1, 2009; 29 (8): 2118-28.  

Multiple isoforms of beta-TrCP display differential activities in the regulation of Wnt signaling., Seo E, Kim H, Kim R, Yun S, Kim M, Han JK, Costantini F, Jho EH., Cell Signal. January 1, 2009; 21 (1): 43-51.

Ryk cooperates with Frizzled 7 to promote Wnt11-mediated endocytosis and is essential for Xenopus laevis convergent extension movements., Kim GH, Her JH, Han JK., J Cell Biol. September 22, 2008; 182 (6): 1073-82.          

Regulation of activin/nodal signaling by Rap2-directed receptor trafficking., Choi SC, Kim GH, Lee SJ, Park E, Yeo CY, Han JK., Dev Cell. July 1, 2008; 15 (1): 49-61.

Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling., Piao S, Lee SH, Kim H, Yum S, Stamos JL, Xu Y, Lee SJ, Lee J, Oh S, Han JK, Park BJ, Weis WI, Ha NC., PLoS One. January 1, 2008; 3 (12): e4046.          

Identification and expression of XRTN1-A and XRTN1-C in Xenopus laevis., Park EC, Shim S, Han JK., Dev Dyn. December 1, 2007; 236 (12): 3545-53.    

Uncoupling by (--)-epigallocatechin-3-gallate of ATP-sensitive potassium channels from phosphatidylinositol polyphosphates and ATP., Jin JY, Park SH, Bae JH, Cho HC, Lim JG, Park WS, Han J, Lee JH, Song DK., Pharmacol Res. September 1, 2007; 56 (3): 237-47.

Xenopus cDNA microarray identification of genes with endodermal organ expression., Changkyun Park E, Hayata T, Cho KW, Han JK., Dev Dyn. August 1, 2007; 236 (8): 2367.

Xenopus cDNA microarray identification of genes with endodermal organ expression., Park EC, Hayata T, Cho KW, Han JK., Dev Dyn. June 1, 2007; 236 (6): 1633-49.                    

Essential role for beta-arrestin 2 in the regulation of Xenopus convergent extension movements., Kim GH, Han JK., EMBO J. May 16, 2007; 26 (10): 2513-26.

The Rtt109-Vps75 histone acetyltransferase complex acetylates non-nucleosomal histone H3., Han J, Zhou H, Li Z, Xu RM, Zhang Z., J Biol Chem. May 11, 2007; 282 (19): 14158-64.

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