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Profile Publications(117)

Publications By Nathan Dascal

Results 1 - 50 of 117 results

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Andersen-Tawil Syndrome Is Associated With Impaired PIP2 Regulation of the Potassium Channel Kir2.1., Handklo-Jamal R, Meisel E, Yakubovich D, Vysochek L, Beinart R, Glikson M, McMullen JR, Dascal N, Nof E, Oz S., Front Pharmacol. January 1, 2020; 11 672.                

A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors., Berlin S, Artzy E, Handklo-Jamal R, Kahanovitch U, Parnas H, Dascal N, Yakubovich D., Front Pharmacol. January 1, 2020; 11 1216.                  

Mutual action by Gγ and Gβ for optimal activation of GIRK channels in a channel subunit-specific manner., Tabak G, Keren-Raifman T, Kahanovitch U, Dascal N., Sci Rep. January 1, 2019; 9 (1): 508.                    

Protein kinase C enhances plasma membrane expression of cardiac L-type calcium channel, CaV1.2., Raifman TK, Kumar P, Haase H, Klussmann E, Dascal N, Weiss S., Channels (Austin). November 2, 2017; 11 (6): 604-615.

Protein kinase A regulates C-terminally truncated CaV 1.2 in Xenopus oocytes: roles of N- and C-termini of the α1C subunit., Oz S, Pankonien I, Belkacemi A, Flockerzi V, Klussmann E, Haase H, Dascal N., J Physiol. January 1, 2017; 595 (10): 3181-3202.

Interactions between N and C termini of α1C subunit regulate inactivation of CaV1.2 L-type Ca(2+) channel., Benmocha Guggenheimer A, Almagor L, Tsemakhovich V, Tripathy DR, Hirsch JA, Dascal N., Channels (Austin). January 1, 2016; 10 (1): 55-68.

A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ., Yakubovich D, Berlin S, Kahanovitch U, Rubinstein M, Farhy-Tselnicker I, Styr B, Keren-Raifman T, Dessauer CW, Dascal N., PLoS Comput Biol. November 1, 2015; 11 (11): e1004598.                  

Molecular Aspects of Modulation of L-type Calcium Channels by Protein Kinase C., Weiss S, Dascal N., Curr Mol Pharmacol. January 1, 2015; 8 (1): 43-53.

Recruitment of Gβγ controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1., Kahanovitch U, Tsemakhovich V, Berlin S, Rubinstein M, Styr B, Castel R, Peleg S, Tabak G, Dessauer CW, Ivanina T, Dascal N., J Physiol. December 15, 2014; 592 (24): 5373-90.

Conserved charged residues at the surface and interface of epithelial sodium channel subunits--roles in cell surface expression and the sodium self-inhibition response., Edelheit O, Ben-Shahar R, Dascal N, Hanukoglu A, Hanukoglu I., FEBS J. April 1, 2014; 281 (8): 2097-111.

Dual regulation of G proteins and the G-protein-activated K+ channels by lithium., Farhy Tselnicker I, Tsemakhovich V, Rishal I, Kahanovitch U, Dessauer CW, Dascal N., Proc Natl Acad Sci U S A. April 1, 2014; 111 (13): 5018-23.

Competitive and non-competitive regulation of calcium-dependent inactivation in CaV1.2 L-type Ca2+ channels by calmodulin and Ca2+-binding protein 1., Oz S, Benmocha A, Sasson Y, Sachyani D, Almagor L, Lee A, Hirsch JA, Dascal N., J Biol Chem. May 3, 2013; 288 (18): 12680-91.

Molecular basis of the facilitation of the heterooligomeric GIRK1/GIRK4 complex by cAMP dependent protein kinase., Treiber F, Rosker C, Keren-Raifman T, Steinecker B, Gorischek A, Dascal N, Schreibmayer W., Biochim Biophys Acta. April 1, 2013; 1828 (4): 1214-21.              

Early infantile epileptic encephalopathy associated with a high voltage gated calcium channelopathy., Edvardson S, Oz S, Abulhijaa FA, Taher FB, Shaag A, Zenvirt S, Dascal N, Elpeleg O., J Med Genet. February 1, 2013; 50 (2): 118-23.

Ca(V)1.2 I-II linker structure and Timothy syndrome., Almagor L, Chomsky-Hecht O, Ben-Mocha A, Hendin-Barak D, Dascal N, Hirsch JA., Channels (Austin). November 1, 2012; 6 (6): 468-72.

Modulation of distinct isoforms of L-type calcium channels by Gq-coupled receptors in Xenopus oocytes: Antagonistic effects of Gβγ and protein kinase C., Weiss S, Keren-Raifman T, Oz S, Ben Mocha A, Haase H, Dascal N., Channels (Austin). September 18, 2012; 6 (6): .

The role of a voltage-dependent Ca2+ channel intracellular linker: a structure-function analysis., Almagor L, Chomsky-Hecht O, Ben-Mocha A, Hendin-Barak D, Dascal N, Hirsch JA., J Neurosci. May 30, 2012; 32 (22): 7602-13.

Two distinct aspects of coupling between Gα(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled Gα(i3) protein subunits., Berlin S, Tsemakhovich VA, Castel R, Ivanina T, Dessauer CW, Keren-Raifman T, Dascal N., J Biol Chem. September 23, 2011; 286 (38): 33223-35.

CaBP1 regulates voltage-dependent inactivation and activation of Ca(V)1.2 (L-type) calcium channels., Oz S, Tsemakhovich V, Christel CJ, Lee A, Dascal N., J Biol Chem. April 22, 2011; 286 (16): 13945-53.

Identification of the roles of conserved charged residues in the extracellular domain of an epithelial sodium channel (ENaC) subunit by alanine mutagenesis., Edelheit O, Hanukoglu I, Dascal N, Hanukoglu A., Am J Physiol Renal Physiol. April 1, 2011; 300 (4): F887-97.

A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews., Laish-Farkash A, Glikson M, Brass D, Marek-Yagel D, Pras E, Dascal N, Antzelevitch C, Nof E, Reznik H, Eldar M, Luria D., J Cardiovasc Electrophysiol. December 1, 2010; 21 (12): 1365-72.

Further characterization of regulation of Ca(V)2.2 by stargazin., Tselnicker I, Dascal N., Channels (Austin). September 1, 2010; 4 (5): 351-4.

Stargazin modulates neuronal voltage-dependent Ca(2+) channel Ca(v)2.2 by a Gbetagamma-dependent mechanism., Tselnicker I, Tsemakhovich VA, Dessauer CW, Dascal N., J Biol Chem. July 2, 2010; 285 (27): 20462-71.

Truncated beta epithelial sodium channel (ENaC) subunits responsible for multi-system pseudohypoaldosteronism support partial activity of ENaC., Edelheit O, Hanukoglu I, Shriki Y, Tfilin M, Dascal N, Gillis D, Hanukoglu A., J Steroid Biochem Mol Biol. March 1, 2010; 119 (1-2): 84-8.

G alpha(i) and G betagamma jointly regulate the conformations of a G betagamma effector, the neuronal G protein-activated K+ channel (GIRK)., Berlin S, Keren-Raifman T, Castel R, Rubinstein M, Dessauer CW, Ivanina T, Dascal N., J Biol Chem. February 26, 2010; 285 (9): 6179-85.

Characterization of the calmodulin-binding site in the N terminus of CaV1.2., Benmocha A, Almagor L, Oz S, Hirsch JA, Dascal N., Channels (Austin). September 1, 2009; 3 (5): 337-42.

Divergent regulation of GIRK1 and GIRK2 subunits of the neuronal G protein gated K+ channel by GalphaiGDP and Gbetagamma., Rubinstein M, Peleg S, Berlin S, Brass D, Keren-Raifman T, Dessauer CW, Ivanina T, Dascal N., J Physiol. July 15, 2009; 587 (Pt 14): 3473-91.

Amplitude histogram-based method of analysis of patch clamp recordings that involve extreme changes in channel activity levels., Yakubovich D, Rishal I, Dessauer CW, Dascal N., J Mol Neurosci. March 1, 2009; 37 (3): 201-11.

An inactivation gate in the selectivity filter of KCNQ1 potassium channels., Gibor G, Yakubovich D, Rosenhouse-Dantsker A, Peretz A, Schottelndreier H, Seebohm G, Dascal N, Logothetis DE, Paas Y, Attali B., Biophys J. December 15, 2007; 93 (12): 4159-72.

Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia., Nof E, Luria D, Brass D, Marek D, Lahat H, Reznik-Wolf H, Pras E, Dascal N, Eldar M, Glikson M., Circulation. July 31, 2007; 116 (5): 463-70.

Galphai3 primes the G protein-activated K+ channels for activation by coexpressed Gbetagamma in intact Xenopus oocytes., Rubinstein M, Peleg S, Berlin S, Brass D, Dascal N., J Physiol. May 15, 2007; 581 (Pt 1): 17-32.

Movement of ''gating charge'' is coupled to ligand binding in a G-protein-coupled receptor., Ben-Chaim Y, Chanda B, Dascal N, Bezanilla F, Parnas I, Parnas H., Nature. November 2, 2006; 444 (7115): 106-9.

Regulation of maximal open probability is a separable function of Ca(v)beta subunit in L-type Ca2+ channel, dependent on NH2 terminus of alpha1C (Ca(v)1.2alpha)., Kanevsky N, Dascal N., J Gen Physiol. July 1, 2006; 128 (1): 15-36.                

Coupling of GABAB receptor GABAB2 subunit to G proteins: evidence from Xenopus oocyte and baby hamster kidney cell expression system., Uezono Y, Kanaide M, Kaibara M, Barzilai R, Dascal N, Sumikawa K, Taniyama K., Am J Physiol Cell Physiol. January 1, 2006; 290 (1): C200-7.

Gbetagamma-dependent and Gbetagamma-independent basal activity of G protein-activated K+ channels., Rishal I, Porozov Y, Yakubovich D, Varon D, Dascal N., J Biol Chem. April 29, 2005; 280 (17): 16685-94.

Kinetic modeling of Na(+)-induced, Gbetagamma-dependent activation of G protein-gated K(+) channels., Yakubovich D, Rishal I, Dascal N., J Mol Neurosci. January 1, 2005; 25 (1): 7-19.

A retinal-specific regulator of G-protein signaling interacts with Galpha(o) and accelerates an expressed metabotropic glutamate receptor 6 cascade., Dhingra A, Faurobert E, Dascal N, Sterling P, Vardi N., J Neurosci. June 23, 2004; 24 (25): 5684-93.

G protein-activated K+ channels: a reporter for rapid activation of G proteins by lysophosphatidic acid in Xenopus oocytes., Itzhaki Van-Ham I, Peleg S, Dascal N, Shapira H, Oron Y., FEBS Lett. April 23, 2004; 564 (1-2): 157-60.

Galphai1 and Galphai3 differentially interact with, and regulate, the G protein-activated K+ channel., Ivanina T, Varon D, Peleg S, Rishal I, Porozov Y, Dessauer CW, Keren-Raifman T, Dascal N., J Biol Chem. April 23, 2004; 279 (17): 17260-8.

Intracellular Na+ inhibits voltage-dependent N-type Ca2+ channels by a G protein betagamma subunit-dependent mechanism., Blumenstein Y, Maximyuk OP, Lozovaya N, Yatsenko NM, Kanevsky N, Krishtal O, Dascal N., J Physiol. April 1, 2004; 556 (Pt 1): 121-34.

Modulation of cardiac Ca2+ channel by Gq-activating neurotransmitters reconstituted in Xenopus oocytes., Weiss S, Doan T, Bernstein KE, Dascal N., J Biol Chem. March 26, 2004; 279 (13): 12503-10.

Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel., Ivanina T, Rishal I, Varon D, Mullner C, Frohnwieser-Steinecke B, Schreibmayer W, Dessauer CW, Dascal N., J Biol Chem. August 1, 2003; 278 (31): 29174-83.

The M2 muscarinic G-protein-coupled receptor is voltage-sensitive., Ben-Chaim Y, Tour O, Dascal N, Parnas I, Parnas H., J Biol Chem. June 20, 2003; 278 (25): 22482-91.

Na+ promotes the dissociation between Galpha GDP and Gbeta gamma, activating G protein-gated K+ channels., Rishal I, Keren-Raifman T, Yakubovich D, Ivanina T, Dessauer CW, Slepak VZ, Dascal N., J Biol Chem. February 7, 2003; 278 (6): 3840-5.

Expression of Bcl-x(S) in Xenopus oocytes induces BH3-dependent and caspase-dependent cytochrome c release and apoptosis., Braun T, Dar S, Vorobiov D, Lindenboim L, Dascal N, Stein R., Mol Cancer Res. January 1, 2003; 1 (3): 186-94.

A novel long N-terminal isoform of human L-type Ca2+ channel is up-regulated by protein kinase C., Blumenstein Y, Kanevsky N, Sahar G, Barzilai R, Ivanina T, Dascal N., J Biol Chem. February 1, 2002; 277 (5): 3419-23.

G(alpha)(i) controls the gating of the G protein-activated K(+) channel, GIRK., Peleg S, Varon D, Ivanina T, Dessauer CW, Dascal N., Neuron. January 3, 2002; 33 (1): 87-99.

Voltage clamp recordings from Xenopus oocytes., Dascal N., Curr Protoc Neurosci. May 1, 2001; Chapter 6 Unit 6.12.

Expression levels of RGS7 and RGS4 proteins determine the mode of regulation of the G protein-activated K(+) channel and control regulation of RGS7 by G beta 5., Keren-Raifman T, Bera AK, Zveig D, Peleg S, Witherow DS, Slepak VZ, Dascal N., FEBS Lett. March 9, 2001; 492 (1-2): 20-8.

Expression cloning of KCRF, a potassium channel regulatory factor., Keren-Raifman T, Ivanina T, Bismuth Y, Dascal N., Biochem Biophys Res Commun. August 11, 2000; 274 (3): 852-8.

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